Resources

Filters

Research Areas
Select Research Area

Species-specific liver microtissues: a set of micro-physiological systems to study the species differences in drug-induced liver injury

Initial evaluation of the use of human liver microtissues for the hepatotoxicity assessment of antisense oligonucleotides

On the relevance of human liver microtissues for the detection of hepatoxic drugs early in the drug development process

Patient-derived steatotic hepatocytes reveal non-cell autonomous inflammation and fibrogenic effects in multicellular liver spheroids

InSphero MASH CALL Flyer

ARCTisâ„¢ Cryo Tissues - How to prepare plate

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

RNA Seq Analysis - Sample EXTENDED Report

RNA Seq Analysis - Sample GENE MINING Report

RNA Seq Analysis - Sample BASIC Report

InSphero MASH CALL Initiative Overview

Predicting Metabolism-Related Drug-Drug Interactions with Organ-on-a-Chip Technology

Scalable 3D Cell Culture Technologies Engineered for Physiological InSight

Implementing High Resolution, High Content Image Analysis with Multicellular 3D Spheroid Models

Optimizing High-Content Imaging of 3D Models for Drug Discovery

A Novel Framework for Teasing Out Mechanisms of DILI

Optimizing 3D Spheroid Models for Efficient Drug-Induced Liver Injury Screening

How to Evaluate Preclinical and Clinical DILI

Novel Lipidomic-based Approach to Liver Drug Safety

A Novel, High-Resolution Perifusion Platform for Studying Insulin Release Dynamics of Single Human Pancreatic Islets

Redefining NASH Drug Discovery: A New Approach to Complex Disease Modeling

Modeling NAFLD: From Steatosis to NASH and Fibrosis

Artificial Intelligence in Digital Pathology: Quantification of Fibrosis in Human 3D NASH Model

InSphero and Hamilton collaborate to improve the production and handling of spheroids

3D InSightâ„¢ Human Islet Microtissues as an in vitro and an in vivo model system for Type 1 and Type 2 Diabetes

InSphero Islet Biology - picking islets for diabetes research

Human 3D in vitro NASH model for efficacy testing of clinical drug candidates

Manual medium exchange under 2 minutes with InSphero Akuraâ„¢ 96 Spheroid Microplate

InFloatâ„¢ Shipping Solution for 3D InSightâ„¢ Assay-ready Microtissues

How we applied InSphero technology to create a human liver NASH model

Akuraâ„¢ Flow Organ-on-a-Chip Technology

Three-dimensional renal organoids from whole kidney cells: generation, optimization, and potential application in nephrotoxicology in vitro

Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids

Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis

In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening

Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro

miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages

Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a -Adrenoreceptor-Dependent Mechanism

Patient-derived tumor spheroid cultures as a promising tool to assist personalized therapeutic decisions in breast cancer

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

Heterologous Protein Production Capacity of Mammalian Cells in 2D and 3D cultures

Scaffold-free cell delivery for use in regenerative medicine

A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-Assembly of Microtissue Building Blocks

Microscale tissue engineering using gravity-enforced cell assembly

3D Cell Culture for Compound De-Risking

An in vitro osteosarcoma 3D microtissue model for drug development

Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine

A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment

A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery

Multi-cell type human liver microtissues for hepatotoxicity testing

Cell culture: A better brew

Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver

Hepatic toxicology following single and multiple exposure of nanomaterials utilising a novel primary human 3D liver microtissue model

Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues

High-throughput imaging: Focusing in on drug discovery in 3D

A High-Throughput–Compatible 3D Microtissue Co-culture System for Phenotypic RNAi Screening Applications

3D cell culture systems modeling tumor growth determinants in cancer target discovery

Development of an innovative 3D cell culture system to study tumour–stroma interactions in non-small cell lung cancer cells

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer

Evaluation of assays for drug efficacy in a three-dimensional model of the lung

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Transcriptomic, Proteomic, and Functional Long-term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

Translational Safety: The Next Frontier for 3D In Vitro Liver Toxicity Testing

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization

Expression Analysis of Exosomal MicroRNAs in Chlorpromazine Treated Human Hepatic Spheroids: A Promising Tool for Novel Drug-Induced Liver Injury Biomarker Discovery

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Characterization and Drug Sensitivity Testing of HTS-Compatible Cancer Microtissues

Multiplexed Drug Assessment in 3D. Combining Luminescence and Fluorescence Genetic Reporters to Assess Drug Effects

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

Special Report on Cancer: Aiming for Avatars

Tracing Clonal Dynamics Reveals that Two-and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma

Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets

Identification of proliferative and mature ß-cells in the islets of Langerhans

Multifunctional in vivo imaging of pancreatic islets during diabetes development

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Targeted delivery of antisense oligonucleotides to pancreatic β-cells

Modelling the endocrine pancreas in health and disease

Glucose, Adrenaline and Palmitate antagonistically regulate insulin and glucagon secretion in human pseuodislets

Targeted pharmacological therapy restores β-cell function for diabetes remission

In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

A microfluidic hanging-​drop-based islet perifusion system for studying glucose-​stimulated insulin secretion from multiple individual pancreatic islets

Translational assessment of a genetic engineering methodology to improve islet function for transplantation

HIF-1alpha inhibitor PX-478 preserves pancreatic beta cell function in diabetes

Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes

Effect of IL4 and IL10 on a human in vitro type 1 diabetes model

Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes

Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis

Considerations for engineering composable, disease-tunable 3D human microtissues for drug discovery

Scroll to Top

Your Success is Our Mission - Get in Touch

Fill in form below to contact our 3D in vitro experts

Sign up for our Newsletter - Get the latest news on 3D in vitro research

View resource

Fill in the form below to view this resource