Discover the 3Rs of InSphero 3D InSight™ Microtissue Platforms
Relevance. Robustness. Reproducibility.
Visit InSphero at the 10th World Congress in Seattle to learn how our advanced 3D microtissues are raising the bar with physiologically relevant in vitro models that can help reduce the use of in vivo animal studies in drug discovery and development.
- Relevant – using primary human-derived cells, our liver, islet and tumor models enables in vitro efficacy and safety studies that are more predictive of the in vivo response in humans
- Robust – culturing primary cells in a scaffold-free 3D format results in more in vivo-like tissue structure and functionality, and extends the in vitro longevity of the model, allowing for long-term, repeat dose drug exposure studies
- Reproducible – our 3D Select™ Process and patented 96-well assay platform ensure unrivaled physiological robustness, with the consistency and automation-friendly assay formats to meet industry-scale screening demands
Achieve DILI prediction with 2X the sensitivity of 2D PHH assays
AstraZeneca and Genentech put 3D InSight™ Human Liver Microtissues to the test against 110 clinically defined DILI compounds. Read the summary of the landmark Archives of Toxicology 2017 paper and download it for your summer science reading list.
Investigate mechanisms of toxicity with our new in vitro 3D monkey liver model
Now you can translate and troubleshoot hepatotoxicity detected in in vivo cynomolgus monkey studies using an in vitro 3D monkey liver model. 3D InSight™ Monkey Liver Microtissues are an organotypic co-culture of primary cynomolgus hepatocytes retaining the advanced, integrated biology required for species-specific studies in investigative toxicology. Visit booth 407 to learn more!
Accelerate diabetes drug discovery with standardized pancreatic islet microtissues
3D InSight™ Islet Microtissues are uniform, functionally robust, and long-lived primary islets delivered pre-qualified and assay-ready for studying islet function, regeneration and preservation. Gain 13-fold glucose-responsive insulin secretion in a highly reproducible primary human model that eliminates tedious hand-picking! View our islet poster presentation.
Your 3D InSight™ Conference Planner
August 20-24, 2017
Washington State Convention Center, Seattle, WA USA
View the 10th WC Online Program