Fairs, Conferences and Events Archive

12 - 16.03.2017 - SOT 56th Annual Meeting and ToxExpo

 

Predict DILI with greater confidence

De-risk drug development with standardized 3D liver microtissues

3D Liver Microtissues for DILI Prediction
Visit InSphero at the 56th Annual Meeting of the Society of Toxicology to learn how our standardized 3D liver microtissues can help you predict drug-induced liver injury (DILI) with high sensitivity, without sacrificing specificity.  With PHH-derived liver microtissues in our new GravityTRAP™ 384 Microtissue Platform, and the launch of 3D Cynomolgus Monkey Liver Microtissues, you can now harness the full power of 3D liver spheroids from HTS to mechanistic and investigative tox studies. Hope to see you in Baltimore!   

 

What's New at SOT 2017

Sneak Peek:  Achieve higher throughput and greater relevance with 384-well Human Liver Microtissues

HTS DILI prediction meets 3D PHH GravityTRAP 384 Microtissue Platform for DILI Screening

What do HepG2, HepaRG, THLE, and iPSC-derived hepatocytes have in common?  They are all cell types researchers use to try to replicate fully differentiated, functional primary human hepatocytes (PHH), but these cells all fall short in one or more ways.  At ToxExpo 2017, we'll be previewing our new GravityTRAP™ 384 Microtissue Platform, which enables early-stage, short term DILI screening in a spheroid-optimized high-throughput format compatible with today's state-of-the-art liquid handling and high content imaging systems. You'll soon be able to harness the benefits of working in high throughput AND using a physiologically relevant PHH-derived DILI model.   

 

3D InSight™ Monkey Liver Microtissues

In vitro cyno: monkey microtissues for mechanistic & investigative tox

3D InSight Monkey Liver MicrotissuesNow you can translate and troubleshoot hepatotoxicity detected in in vivo cynomolgus monkey studies using an in vitro 3D monkey liver model.  At ToxExpo 2017, we'll be launching our new 3D InSight™ Monkey Liver Microtissues. This organotypic co-culture of primary cynomolgus hepatocytes retains the advanced, integrated biology required for species-specific studies in investigative toxicology.

   

Your 3D InSight™ Conference Planner

Conference Dates
March 12-16, 2017

Venue
Baltimore Convention Center, Baltimore, MD  USA


Booth
1102

Download the SOT Meeting App
View the SOT Online Program

  Oral Presentations

Exhibitor Hosted Session

Wednesday, 3:00 - 4:00 PM, CC Room 338
Advanced 3D Liver and Pancreatic Islet Microtissues for Safety and Efficacy Assessments
3D liver and pancreatic islet microtissues for safety and efficacy testing will be presented, highlighting data from a 110 compound validation study for predictive DILI, and mechanistic assessments for investigative toxicology. Novel data on the use of 3D Islet Microtissues for diabetes research and pancreatic safety will also be discussed.

SMe SOT2017 InSphero Microtissue Presentation

Presented by Dr. Simon Messner, InSphero AG

Recommended Workshop Presentation

Wednesday, 9:30 AM - 12:15 PM, Room 321
An Industry Perspective on New and Emerging In Vitro Models for Assessing Hepatotoxicity Risk in Drug Discovery
Final Presentation in Workshop Session:  3D Cell Platforms to Advance Toxicological Sciences
Presented by Dr. Will Proctor, Genentech, Inc.

Poster Presentations

sot2017poster

Monday, March 13, 9:30 AM - 12:45 PM
1253/P413: Assessment of Mitochondrial Activity in 3D Human Liver Microtissues As a Tool for Mechanistic Investigations of Adverse Drug Effects
Presented with Agilent Technologies

InSphero xspecies Posters at SOT 2017

Tuesday, March 14, 9:30 AM - 12:45 PM
1651/P103: Evaluation of Species-Specific Drug-Induced Liver Injury in 3D Rat, Dog, Monkey, and Human Liver Microtissues

3D InSight Monkey Liver Poster

Wednesday, March 15 1:15 PM - 4:30 PM
2763/P131: Establishment and Characterization of 3D Monkey Liver Microtissues for Species-Specific Toxicity Testing
 

Presented with Genentech

 

09 - 12.03.2017 - Keystone Symposia: Engineered Cells and Tissues as Platforms for Discovery and Therapy

Keystone Symposia K1

Join InSphero CSO Patrick Guye and East Coast Director of Sales Brian Manning at one of our poster presentations, or podium discussions.

Engineered Cells and Tissues as Platforms for Discovery and Therapy

The meeting will begin on Thursday, March 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Sunday, March 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. 

 

Conference Date
09 - 13 March, 2017

Venue

Fairmont Copley Plaza, Boston, Massachusetts, USA

View the Conference Program

Posters and Podium Presentations

Podium Presentation: A Microfluidic Multi-tissue Culturing Platform Based on 3D Microtissues Spheroids
Olivier Frey, David Fluri, Patrick Guye (presenter), Brian Manning, Jens Kelm

Poster: 3D tumor/stroma co-culture spheroid models for immuno-oncology applications
Irina Agarkova, Tamara Tanos, Francesca Chiovaro, Sumeer Dhar, Patrick Guye, Jens Kelm

 

 

02.03.2017 - Salon des Technologies et de L`innovation de Lausanne (STIL)

STIL Cover

Full-day event on 3D microtissue models for more relevant translational screening methods and safety testing.

Located at the SwissTech Convention Center recently inaugurated on the EPFL campus, the salon offers 3700 m2 of space for its exhibitors and desires to be accessible to broad public. This interdsciplinary exhibition represents a great way to share and discuss about the last breakthrough in the filed of technology.

The purpose of the day is to give an interesting and playful way for the visitors to discover the technologies of the different laboratories and enterprises

 

Date:
2nd of March, 2017

Venue:
SwissTech Convention Center
EPEL Campus
Route Louis-Favre 2, 1024 Ecublens VD (Lausanne)

more Infos

14.03.2017- InSphero Beers and Spheres Social - SOT 2017

04. - 08.02.2017 - SLAS 2017 6th Annual Conference & Exhibition, Washington DC, USA

SLAS2017

GravityTRAP™ 384 Microtissue Platform | SLAS2017 Conference Planner | Get 3D Screening InSight

The annual conference of the Society of Laboratory Automation and Screening (SLAS) is where science research and development professionals gather to learn about the latest and greatest laboratory tools and technologies available and how they are being applied by their peers. InSphero scientists will be available to discuss 3D screening technologies at SLAS2017 Booth #213.

 

384 reasons to talk to InSphero at SLAS2017

GravityTRAP 384 Microtissue Platform

This year, InSphero will be previewing our new GravityTRAP™ 384 Microtissue Platform, which is engineered to:

  • Enhance high content imaging quality with a continuous, flat bottom glass base plate, and a black-walled body to eliminate fluorescent crosstalk between wells
  • Prevent unintended microtissue aspiration during medium exchange with distinct culture and media chambers featuring our unique SureXchange™ ledge
  • Simplify microtissue localization, observation, and ROI identification with standard 1 mm diameter observation chambers

Starting in 2017, InSphero will begin delivering 3D InSight™ Microtissues in our GravityTRAP™ 384 format, which is ideal for HTS applications such as:

See for yourself at SLAS2017!

Stop by Booth #213 to learn more about 3D InSight™ Microtissues, view our in-booth poster hall, and This email address is being protected from spambots. You need JavaScript enabled to view it. to receive exclusive pre-launch GravityTRAP™ 384 product announcements.

Watch VideoDownload reminder card 

 

Your 3D InSight™ Conference Planner

Conference Dates 
February 4–8, 2017

Venue
Walter E. Washington Convention Center
801 Mt Vernon Pl NW, Washington, DC 20001, USA

Booth
Meet InSphero 3D microtissue experts at Booth #213

Schedule
SLAS2017 Event Scheduler

 

InSphero Educational Events

Saturday, February 4, 8:30 AM – 4:30 PM 

Dr. Jens M. Kelm

Short Course: 3D Cell-Based Assays for Drug De-Risking

Instructors: Dr. Jens M. Kelm, InSphero; Dr. Helena Hogberg, CAAT/Johns Hopkins University; Dr. Terry Riss, Promega Corp.

Cell-based in vitro assays are used throughout the drug discovery and development chain, allowing for high throughput efficacy but also mechanistic-based toxicity testing. A big challenge however is the translation of in vitro assays towards the in vivo outcome. Physiological relevance is a key parameter to improve the predictive power of cell-based assays. The better we can reflect tissue architecture, composition and function the more predictive an in vitro assay will become. The 3D course covers advances in 3D cell culture technologies, assays and their use in drug discovery and development.

View the Course Outline or Register Online


Tuesday, February 7, 1 – 3 PM

Dr. Jens M. Kelm

Poster #1298: Assessment of tumor recurrence with an in vitro 3D tumor microtissue model

Authors: Drs. Sumeer Dhar, David Fluri, and Jens M. Kelm

Short Abstract: Here we present a novel in vitro tumor relapse assay method based on a 3-dimensional tumor microtissue model, to enable compound classification based on their efficiency to prevent tumor relapse.  Read more...

 

Get 3D Screening InSight

InSphero can help you begin or advance your screening in physiologically relevant 3D models for toxicology, diabetes, and oncology. Our microtissue technology experts will be at SLAS2017, and we’d love to talk to you about how you can gain 3D InSight™ using our products and services:

08. - 11.02.2017 - Alberta-BC Islet Workshop 2017

Alberta Cover

 

A-BC Workshop 2017

Date:
February 8-11, 2017

 

Venue:
Silver Star Mountain Resort, BC
123 Shortt Street
Silver Star Mountain
BC Canada V1B 3M1

more Infos

04. - 07.09.2016 - EUROTOX 2016

  Eurotox Startbild

Liver Microtissues | 3 Steps to 3D | Posters

Meet InSphero at EUROTOX2016, the 52nd European Congress of the European Societies of Toxicology, to learn more about how 3D InSight™ Microtissues and Services can help you evaluate, adopt, and integrate our next-generation 3D models into your safety testing workflow. We’ll be introducing our 3D InSight™ Mitotoxicity Testing Service, an advanced functional mitochondrial toxicity assay that combines the Seahorse XFe96 Platform with 3D InSight™ Human Liver Microtissues (Visit poster P16-017). It’s the latest addition to our menu of 3D InSight™ In Vitro Toxicology Services, which allow you to leverage our 3D expertise and extend your scientific staff.

Stop by our posters, or visit us at Booth #12 to talk to an InSphero representative about how you can take advantage of our solutions for toxicology in your research.

 

Discover our most powerful 3D liver model for predicting DILI

Human Liver MT neu

3D InSight™ Human Liver Microtissues are developed from pooled hepatocytes isolated from 10 donors (5 male, 5 female) co-cultured with Kupffer cells, and are ideal for DILI testing and mechanistic toxicity studies. Multi-donor hepatocytes more closely approximate the average human response, mitigate potentially confounding responses resulting from single-donor CYP polymorphisms, and extend donor lot availability to ensure a long-term supply of donor material. (Visit poster P08-035)

 

3 Steps to 3D Integration

The world’s leading pharmaceutical companies have integrated InSphero 3D InSight™ Liver Microtissues into their DILI testing workflow. Now we’ve made it simple for you.
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Evaluate
With our 3D InSight™ DILI Evaluation Service, you evaluate our next-generation human liver microtissues by letting our experts do all the work. We test 6 of your compounds and determine an IC50 using a 14 day, repeat-dosing protocol with ATP endpoint in our 3D InSight™ Human Liver Microtissue model. You get the results to compare to our reference compound data in just 3 weeks.

Adopt
Our 3D InSight™ DILI Evaluation Kit helps get you started using our liver microtissue models in-house. It includes human liver microtissues, optimized media, 6 reference compounds, ATP assay reagents, and a detailed protocol to simplify in-house adoption of InSphero microtissues—everything you need to predict the DILI risk for up to six compounds of interest. As you implement the 3D protocol, you’ll also be validating the results of your evaluation project. You get the full support of our 3D experts, and in about 3 weeks you'll be ready to integrate our advanced 3D models into your workflow.

Integrate
Microtissues are available weekly for delivery to your lab. Your can order plates of 3D InSight™ Microtissues as you need them - – or plan ahead using our online microtissue production schedule. Enjoy the assay-ready convenience of standardized 3D liver models and optimized media delivered to your lab, and rest assured you’re using the most reliable and biologically relevant in vitro DILI testing model available. Focus on the results, and leave the production and QC to InSphero.

 

Your 3D InSight™ Planner for EUROTOX2016

Congress Date
04. - 07. September, 2016

Venue
FIBES, Conference and Exhibition Centre (Seville, Spain)

Booth
12 

Posters

Poster Session I: 5 September 2016 (12-14pm)

P01-009: Evaluation of Species-specific Drug-induced Liver Injury in 3D Rat, Dog, Monkey and Human Liver Microtissues
Presented by Dr. Monika Kijanska

P06-035: 3D Hepatic Spheroid Models for the Detection and Study of Compounds with Cholestatic Liability
Presented by Dr. Simon Messner

P08-035: Characterization and Application of 3D Multi-Donor Human Liver Microtissues for Predictive DILI Testing and Mechanistic Investigations
Presented by Dr. Monika Kijanska

P08-053: Characterization of a Novel In Vitro 3D Skin Microtissue Model for Efficacy and Toxicity Testing
Presented by Dr. Monika Kijanska

P08-059: A Novel Standardized In Vitro Islet Model System for Efficacy and Toxicity Testing in Pancreatic β-cells
Presented by Dr. Simon Messner

Poster Session II: 6 September 2016 (12-14pm)

P16-017: Assessment of Mitochondrial Activity in 3D Human Liver Microtissues as a Tool for Mechanistic Investigations of Adverse Drug Effects
Presented by Dr. Simon Messner

07.09.2016 - D-BSSE meets Industry: Dr. Jan Lichtenberg & InSphero - From Lab Bench to a Global Biotech Start-up"

D BSSE meets Industry

InSphero is a spin-off of ETH Zurich and the University Zurich. It is the first commercial producer of organotypic, scaffold-free, 3D microtissues for drug development and screening. In particular, InSphero thereby provides solutions to pharmaceutical and biotechnological companies in the fields of oncology and toxicology.
The company was selected for the Venture Kick Initiative (2009), was awarded the CTI Start-up Label (2010), ranked amongst Switzerland’s Top 10 Start-ups from 2011-2013 and finally was elected Switzerland’s Top Start-up as well as Europe’s Top Life Sciences Academic Enterprise in 2014.
Jan Lichtenberg, CEO and co-founder of InSphero, will talk about his background, his experience in entrepreneurship, and his journey towards founding and running his own start-up.

Date:
September 09, 2016

Time:
6:30pm

Venue:
Science lounge, D-BSSE
Mattenstrasse 26, Basel, Switzerland

Talk:
Talk "Jan Lichtenberg & InSphero -  from lab bench to a global biotech start-up"
by Dr. Jan Lichtenberg (CEO) of InSphero

This email address is being protected from spambots. You need JavaScript enabled to view it.

Find out more aobut the talk by Dr. Jan Lichtenberg at D-BSSE in Basel

Download Meeting Flyer

09.09.2016 - Roche Symposium: Organs on a chip - is the end of animal testing near?

One-Day Symposium

Title: Organs on a chip - is the end of animal testing near?

Date:
September 09, 2016

Time:
08:15am- 14:00pm

Venue:
Roche Basel
Grenzacherstr. 124, 4070 Basel, Switzerland

Poster:
Evaluation of species-specific drug-induced liver injury in 3D Rat, Dog, Monkey and Human Liver Microtissues
Evaluation of a novel standardized in vitro human islet model system for assessment of drug-related pancreatic β cell functional perturbation

presented by Dr. Jens Kelm

 

organs on a chip - is the end of animal testing near ?

13. - 17.03.2016 - SOT 55th Annual Meeting and ToxExpo

  SOT web logo

Multi-donor Microtissues | Exhibitor-hosted Sessions | Posters | Beers & Spheres Social

Join InSphero at the 55th Annual Meeting of the Society of Toxicology to learn more about how 3D InSight™ Microtissues & Services can help you evaluate, adopt, and integrate advanced 3D models into your safety testing workflow. We’ve got big news to share this year, as we present results from an in-depth characterization of the DILI-predicting capabilities of our 3D liver microtissues, and introduce our newest assay-ready microtissue model: 3D InSight™ Multi-donor Human Liver Microtissues. These multi-donor microtissues pack macro-power, while representing a more diverse genomic background in which to test for drug-induced liver injury. With convenient kit and service options, we’ve made integrating them as easy as 1-2-3, so you can be up and running before summer arrives.

Join us at one of our 11 scientific sessions, socialize at our Monday Beers and Spheres event, or visit us at booth 1844/1845 to browse our in-booth poster hall while enjoying an invigorating beverage.

 

Introducing the ideal model for predicting DILI

banner

3D InSight™ Multi-donor Human Liver Microtissues offer the same structural and functional robustness of our single-donor 3D InSight™ Human Liver Microtissues, while mitigating potentially confounding responses resulting from single-donor CYP polymorphisms. By pooling hepatocytes from 10 donors (5 male, 5 female), multi-donor microtissues more closely approximate the average human response, and extend donor lot availability to ensure a long-term supply of donor material. Available as co-culture with Kupffer cells, multi-donor microtissues are ideal for DILI testing and mechanistic toxicity studies.

 

3 “Big Easy” Steps to 3D Integration

The world’s leading pharmaceutical companies have integrated InSphero 3D InSight™ Liver Microtissues into their DILI testing, now we’ve made it simple for you to do the same.
circles

Evaluate
With our 3D InSight™ DILI Evaluation Service, you evaluate multi-donor microtissues by letting our experts do all the work. We test 6 of your compounds and determine an IC50 using a 14 day, repeat-dosing protocol with ATP endpoint. You get the results to compare to our reference compound data in just 3 weeks.

Adopt
Our 3D InSight™ DILI Evaluation Kit provides enough multi-donor microtissues, optimized media, 6 reference compounds, ATP assay reagents, and a detailed protocol to simplify in-house adoption of InSphero microtissues. As you implement the 3D protocol, you’ll also be validating the results of your evaluation project. You get the full support of our 3D experts, and in about 3 weeks you'll be ready to integrate.

Integrate
Review our regular microtissue production schedule, and order plates of 3D InSight™ Microtissues as you need them. Enjoy the assay-ready convenience of standardized 3D liver models and optimized media delivered to your lab, and the satisfaction of knowing you’re using the most biologically relevant in vitro DILI testing model available. Focus on the results, and leave the production and QC to InSphero.

 

Your 3D InSight™ Conference Planner

Conference Date
13. - 17. March, 2016

Venue
New Orleans Morial Convention Center

Booth
1844/1845

Download the SOT Meeting App
View the SOT Online Meeting Planner

  Exhibitor-hosted Sessions

Monday, 4:30 - 5:30 PM, Room 205
Use of 3D InSightTM Human Liver Microtissues as a Tool for Prediction of Drug-induced Liver Injury
Prediction of DILI is an important task in drug developmment. InSphero will present the results from recent evaluation studies by the pharmaceutical industry using 3D InSight Human Liver Microtissues for prediction of DILI, performed with more than 100 clinically known test compounds.
SMe

Monday, 4:30 - 5:30 PM, Room 211
Functional Assays for Assessing Mitochondrial Toxicants and Other Energy Metabolism Disruptors in Live Cells
presented by Seahorse Bioscience, a part of Agilent Technologies, featuring InSphero Human Liver Microtissues
Portrait


Tuesday, 10:30 - 11:30 AM, Room 213
Combining Real-Time Measurement of Cell Viability and Extraction of RNA from the same 3D Spheroids
presented by Promega Corporation

Tuesday, 4:30 - 5:30 PM, Room 213
Evolution of the Spheroid: Advanced 3D Microtissue Models as a Versatile Tool for more Physiologically Relevant Efficacy and Safety Assessment

3D Microtissues reflect organ physiology more closely than conventional 2D cultures, but are still amenable to automation. Here the recent developments in 3D microtissue technology are presented which allow for high throughput efficacy and safety testing. In addition, incorporation of spheroids into microphysiological systems will be discussed
Portrait

Posters

Monday, March 14, 1:15 - 4:30 PM
1669/P554: Utility of 3D Human Liver Microtissues for Prediction of Compounds that cause Drug-induced Liver Injury in Humans
with AstraZeneca and Genentech

Tuesday, March 15. 1:15 - 4:30 PM
2173/P150: 3D HepaRG Microtissues for Improved ADME/Tox Predictions
with Biopredic

Tuesday, March 15, 1:15 - 5:30 PM
2000/P404: In-depth Characterization of 3D Human Liver Microtissues by Transcriptomic, Proteomic and Functional Analysis
 

with Karolinska Institute

Thursday, March 17, 9:30 AM - 12:45 PM
3460/9150: Pro-drug Activation and Detoxification in a Dynamic Microfluidic System
with ETH Zurich

Thursday, March 17, 9:30 AM - 12:45 PM
3705/P397: Evaluation Of A Novel Standardized In Vitro Human Islet Model System For Assessment Of Drug-related Pancreatic β Cell Functional Perturbation
with Amgen

Thursday, March 17, 09:30 AM - 12:45 PM
3553/P245: Combining a Real-time In Vitro Cell Viability Assay and RNA Extraction From the Same 3D Spheroids
presented by Promega

Thursday, March 17, 9:30 AM - 12:45 PM
3911/P603: Development of a 3D Dog Liver Microtissue Model
with Pfizer

 


Monday Night Beers & Spheres Social

 

 

 

 

 

 

 

12. - 14.09.2016 - 12th Annual APA Meeting

  logo apa

12th Annual Applied Pharmaceutical Analysis (APA) Meeting

Meet InSphero at APA 2016, the 12th Annual APA Meeting in Burlington, MA.

Date:
September 12-14, 2016

Time:
7:00am - 6:30pm (Sep. 12/13)
07:00am  - 6:00pm ( Sep. 14)


Venue:
Boston Marriot Burlington
One Burlington Mall Road
Burlington, MA 01803

more Infos

13.04.2016 - Biovalley Treffpunkt Lörrach

Biovalley 

Stammzellen in Pharmaforschung, Medizintechnik und Anwendung 

Date:
13.April 2016, 19:00 Uhr

Venue:
Konferenzzimmer im Innocel Innovations-Center Lörrach
(1. Stock in der Marie-Curie-Str. 8, D-79539 Lörrach)

Talks:
Creating Tissues from Stem Cells for Drug Development
by Dr. Jens Kelm, CSO and Co-Founder of InSphero AG, Schlieren/CH

Induced pluripotent stem cells (iPS) have become a valuable source for toxicological profiling of drugs in the pharmaceutical industry. However, they are also a valuable cell source to create 3D microtissues in vitro, especially for organs from which it is difficult to obtain primary cells such as the heart and brain. Next to the use of iPS cells other types such as adult stem cells are also being used to re-create tissue structures in the petri dish e.g. the epithelial barrier of the intestine. Here we provide an overview how stem cells can be used to create physiological relevant tissue models in vitro, showcasing heart, brain and intestine.

A preclinical stage biotech developing stem cell-derived treatments for genetic and age-related muscle disease
by Dr. Jean-Yves Bonnefoy, CEO, Anagenesis Biotechnologies SAS, Illkirch/FR

Anagenesis Biotechnologies owns a unique proprietary technology, which is the result of 15 years of research in the laboratory of Pr. Olivier Pourquié, a world expert in the field of musculo-skeletal development and stem cells. His laboratory is particularly interested in paraxial mesoderm, the embryonic tissue that gives rise to skeletal muscle and axial skeleton. Paraxial Mesoderm Multipotent Cells (P2MCs) are shared precursors of skeletal muscle, ribs, vertebrae, dermis, endothelium & brown fat. Anagenesis Biotechnologies’ proprietary technology allows the company to produce muscle cells from stem cells and is based on a unique patent-protected know-how. The priority of the company is to develop new drugs for Duchenne myopathy and then for sarcopenia and cachexia with pharma partners.

registration under: This email address is being protected from spambots. You need JavaScript enabled to view it.

how to get there

16. - 20.04.2016 - AACR 2016

AACR

3D Solutions for Oncology | Posters | In-booth Demonstrations

 

oncologyExpertise

Let's deliver cures for cancer together

It's no secret that 3D cell culture is helping researchers develop more biologically relevant in vitro models for target discovery, and for testing the efficacy of anti-cancer drugs and therapeutic strategies. Many tumor cell lines readily form 3D multi-cellular tumor spheroids (MCTS), providing more physiologically relevant oxygen and nutrient diffusion gradients in which to assess anti-tumor drug efficacy. These models can reveal strikingly different phenotypes and response to drugs compared to the same cells grown in traditional 2D monolayer culture. Advanced 3D models seek to incorporate stromal cell constituents of the tumor microenvironment which play an important role in tumor growth, invasion, metastasis, and immune evasion. More complex in vitro tumor-stromal models such as these must both more accurately reflect this microenvironment, and provide the necessary compatibility with established cell-based assays and high-throughput workflows to successfully translate better biology into new, more effective therapies. 

Since our founding in 2009, InSphero has been focused on only one thing: 3D cell culture. Over the past 7 years, we’ve grown from a supplier of innovative 3D culture technologies to become the industry’s only provider of comprehensive solutions to meet the needs of both simple and complex 3D tumor model development and testing. Leverage our 3D expertise, and get on the path to finding the cures. 

Come see us at Booth #1912, or visit one of our posters to learn more about the use of advanced 3D tumor models for drug efficacy testing.   

DEVELOP

Grow your 3D model in our industry-leading GravityTRAP™ Ultra-low Attachment (ULA) Plate or GravityPLUS™ Hanging Drop System, comprising the only complete offering for production of simple and complex scaffold-free tumor spheroids. Learn which scaffold-free option is best for the model you want to build, place your order, and get started. You can even request a free sample plate from PerkinElmer, the exclusive distributor for InSphero GravityTRAP™ and GravityPLUS™ platforms. Our plates are designed to make the production, long-term culture, assay, and imaging of tumor spheroids as simple, reliable, and automation-compatible as possible. Want to move faster? Contract our 3D experts to develop a customized tumor or tumor-stromal model using our scaffold-free 3D culture platforms. Choose from over 100 established models using authenticated tumor cell lines from a variety of cancer types, alone or in co-culture with fibroblasts.

multi cellular 3D tumor models

Either way, you benefit from fit-for-purpose technology, 3D-optimized media, and the consultation of our 3D experts. 

TEST

Efficacy testing of anti-cancer drugs in 3D models requires a multi-faceted approach to monitoring growth via phenotypic and biochemical means. Our 3D experts can test your drugs, including small molecules, biologics, ADCs, RNAi, and more, in the 3D model or models of your choosing. Our 3D InSight™ Oncology Services utilize a menu of 3D-optimized protocols for common viability and mechanistic endpoints, many using the Cell3iMager for rapid, non-lytic, and label-free assessment of spheroid size. Standard services include:

  • Efficacy testing – Determine the potency (IC50), efficacy (maximum response) and growth kinetics of your drug using size and ATP (viability) over a 10 day dosing regimen
  • Combinatorial drug testing – Determine the potency (IC50), efficacy (maximum response) and growth kinetics of a combination of drugs using size and ATP (viability) over a 10 day dosing regimen
  • Tumor relapse assay – Determine IC50 and IC20 for your drug, then assess tumor recurrence following single-dose vs. continuous treatment over 10 days
  • Antibody penetration – Determine the penetration kinetics of your biological into a tumor spheroid to assess or optimize distribution efficiency

ic50growth profile

CURE

The quest for new cancer cures will require an integrated translational approach, utilizing novel, more biologically relevant 3D models for target discovery and validation, as well as integration of novel assay and imaging technologies to classify drug efficacy and synergism with existing treatment modalities.  

The next cancer breakthroughs could already be within your grasp, but masked or deprioritized by other promising targets or leads identified in suboptimal in vitro models. Revealing them requires the willingness and resources to explore beyond the status quo of monolayer cell culture.  We're here to be your guide and supply you with the tools, models, services, and 3D expertise you need to move forward with unfetttered confidence toward discovering cures and novel treatments.

 

Your 3D InSight™ Conference Planner

Date
April 16 - 20, 2016

Venue
Ernest N. Morial Convention Center, New Orleans

Booth
Meet us at booth 1912

AACR Online Resources
Download the AACR 2016 Meeting App
View the AACR 2016 Online Meeting Planner


InSphero Posters

Visit our posters during AACR poster sessions or view them at your convenience during daily exhibit hours at our booth (#1912).

Sunday, April 17, 1-5 PM

Tumor Biology Poster Session, Section 33:  Targeting the Microenvironment
Poster 30, Abstract 771 – Multi-parametric 3D tumor microtissue-based phenotypic compound classification 
Presenting author:  Madhu A. Lal, National Center for Advancing Translational Sciences (NCATS)
Short abstract: Here, we report on the development of homo- and heterotypic ovarian and pancreatic microtissue tumor models for screening up to 40 compounds selected from the NCATS Oncology focused library of small molecules. The goal of this study was to develop a high throughput compatible drug screening platform that could leverage the best of high throughput and high content screening assays to generate a pharmacological profile of activities that we hope will help better predict activity in vivo.

Sumeer Dhal
Novel Assays Poster Session, Section 18:  Experimental and Molecular Therapeutics
Poster 9, Abstract 358 – Assessment of tumor recurrence with an in vitro 3D tumor microtissue model
Presenting author: Sumeer Dhal, InSphero AG
Short abstract: One of the most pressing problems in the treatment of cancer is tumor relapse. Although many tumors regress in response to neoadjuvant chemotherapy, residual tumor cells are detected in most cancer patients post-treatment. These residual tumor cells are thought to remain dormant for years before resuming growth, resulting in tumor recurrence. Considering that recurrent tumors are most often responsible for patient mortality, there exists an urgent need to study signaling pathways that drive tumor dormancy/recurrence. Current in vitro assays based on monolayer cultures do not provide the required time frame to study tumor recurrence. Here we present a novel in vitro tumor relapse assay method based on a 3-dimensional tumor microtissue model, to enable compound classification based on their efficiency to prevent tumor relapse.

 

In-booth Demonstrations

Our 3D experts will demonstrate the functionality of the Cell3iMager Neo and teach you how to use our scaffold-free culture platforms.

Cell3iMager Neo
A high-throughput bright field scanner for automated, label-free profiling of 3D spheroids

  • Monday, April 18, 1-1:30 PM
  • Tuesday, April 19, 1-1:30 PM

GravityTRAP™ ULA Plates and the GravityPLUS™ Hanging Drop System
Get hands-on with our spheroid plates designed for spheroid users.  

  • Monday, April 18, 10-10:30 AM
  • Tuesday, April 19, 10-10:30 AM

Find out more about the AACR Annual Meeting 2016

 

 

 

 

19. - 21.04.2016 - DECHEMA 3D Cell Culture Conference 2016

DECHEMA

3D Cell Culture 2016: How close to 'in vivo' can we get?
Models, applications & translation

Get updated about 3D cell cultures as predictive, physiological relevant model systems!

These questions will be addressed – and answered – at 3DCC 2016:

What is successfully applied?

What is in development?

Where are still gaps?

The conference will highlight successful applications and newest developments in the key areas of 3D cell culture.

During the conference success stories of 3D culture applications will be presented as well as newest technologies and innovations. Relevant disease models, applications of 3D models in clinic and industry, predictive cell models for compound characterization and enabling technologies will be covered.

Date:
April 19 - 21, 2016

Venue:
Konzerthaus Freiburg, Germany

Booth:
Meet us at booth C1

 Posters/ Talks:

Chair Session: Strategies for High-Throughput Screening and Analysis
by Dr. Jens Kelm of InSphero
Tuesday, April 19 2016 - 16:00

Lecture: Multi-parametric 3D Tumor Microtissue-bases Phenotypic Compound Classification
by Dr. Jens Kelm of InSphero
Wednesday, April 20 2016 - 11:20

Lecture: Adding Metabolic Competence to 3D Spheroid-based Assays by Using a Microfluidc Multi-tissue Culturing Platform
by Dr. Olivier Frey of ETH Zurich
Wednesday, April 20 2016 - 15:05

Poster P 1.1.21: Characterization of cellular features of iPSC-derived human cardiomyocytes and cardiac fibroblasts in 2D standard culture and 3D co-culture
by Dr. Christian Zuppinger of University Hospital Bern

Poster P 1.3.03: Establishment of a 2-week in vitro workflow for repeatdosing of human hepatic and cardiac 3D-microtissues to study clinically relevant side effects of marketed drugs
by Dr. Ramona Nudischer of F.Hoffmann-La Roche Ltd.

Poster P 2.1.02: Cardiac toxicity assessment using iPS-derived human cardiac microtissues
by Dr. Jens Kelm of InSphero

Poster P 2.1.03: In vitro assessment of tumor relapse in a 3D tumor microtissue model
by Dr. Jens Kelm of InSphero

 
Find out more aobut the DECHEMA 3D Cell Culture Conference 2016

18. - 20.05.2016 - Applied Pharmaceutical Toxicology 2016

APT logo 2016

ATP

Date:
May 18 - 20, 2016

Venue:
Novartis Auditorium,Novartis Institutes for BioMedical Research,
250 Massachusetts Ave, Cambridge, MA 02139

Tabletop:

 

Find out more aobut the ATP2016 Conference

10. - 14.06.2016 - American Diabetes Association - 76th Scientific Sessions

ADA

The American Diabetes Association Meeting (ADA 2016) to be held at Ernest N. Morial Convention Center in New Orleans, United States of America, from 10th June to 14th June, 2016, will bring together doctors from all over the globe to a platform where they can share, learn, and explore new techniques and technologies in eye care. The American Diabetes Association Meeting will be attended by more than 15,200 participants from around the world who help in research of better health care strategies and diabetes management. The ADA Scientific Sessions 2016 will offer great scientific sessions, lectures, workshops, and abstracts, which will enable the patients, students as well as professionals to learn and discover new information. The ADA 2016 will also serve as an excellent place to forge new connections with people from the related fields.

Date:
June 10 - 14, 2016

Venue:
Ernest N. Morial Convention Center
New Orleans, USA

Poster:
June 12, 2016 - 12:00 - 02:00 PM - Session LB-01
339-LB/339:
A Novel Standardized In Vitro Islet Model System for Efficacy and Toxicity Testing in Pancreatic ß-Cells
by Dr. Burcak Yesildag of InSphero AG

 

Find out more aobut the ADA Scientific Sessions 2016

14. - 17.06.2016 - World Preclinical Conference 2016 (WPC)

WPC

Where Preclinical Minds meet Discovery Technologies

In recent years, the World Preclinical Congress (WPC) has turned into a key networking event for those involved in preclinical research. It features conferences, training seminars and short courses that cover the very latest in preclinical strategies and technologies, to enable better and faster decisions in drug discovery. WPC attracts a diverse, global audience, which include experts, as well as people who are new and eager to contribute to the field. Having chemists, biologists, pharmacologists, toxicologists, screening and formulation experts in attendance, creates an interesting cross-disciplinary environment for tackling challenges and sharing expertise. Now in its 15th year the event will continue to highlight ways to improve accuracy and efficiency in preclinical research, while bringing together the people and technologies to make it happen.

Date:
June 14 - 17, 2016

Venue:
Westin Boston Waterfront, Boston, MA

Booth:
meet us at booth 204

 

Find out more aobut the WPC 2016

15.06.2016 - Seminar Day & User Meeting on Searhose XF Technology Provides a New Window on Cell Metabolism

Seahorse

This event will be an excellent opportunity to learn about modern ways to measure cellular metabolism. The implication of mitochondrial dysfunction in various diseases will be highlighted as well as the importance of altered metabolism in cancer and tumor immunology research.
The seminar is composed of overview presentations, keynote lectures, discussions and presentations of user data. With this event we want to provide you an overview on the huge impact functional metabolism gained in the past years. Coffee breaks and lunch time will allow for interesting discussions with peer-colleagues and exchange with users of the XF-Analyzer.
Existing XF users will learn about the recent developments of Seahorse Bioscience, discuss on practical issues when designing and running assays as well as deepen their knowledge on tools to interfere with respiration and glycolysis.

Date:
June 15, 2016

Venue:
Olten, Switzerland
(Venue to be announced in your confirmation e-mail upon registration)

User presentation:
15:40 Mitochondrial Activity Assessment in 3D Human Liver Microtissues
Dr. Katrin Rössger of InSphero

Registration:
Your participation is free of charge.
In order to register for the seminar, please send us an e-mail to This email address is being protected from spambots. You need JavaScript enabled to view it. or give us a call under 061 269 11 11

View detailed program here

23. - 24.06.2016 - "Hepatotoxicity Testing based on Adverse Outcome Pathways"

CAAT

Adverse outcome pathways (AOPs) are novel tools in toxicology and human risk assessment with broad potential. AOPs are designed to provide a clear-cut mechanistic representation of critical toxicological effects that span over different layers of biological organization. AOPs share a common structure consisting of a molecular initiating event, a series of intermediate steps and key events, and an adverse outcome.


Elaborate AOP frameworks have been proposed for chemical-induced skin sensitization, cholestasis, liver fibrosis and liver steatosis. These newly postulated AOPs can serve a number of ubiquitous purposes, including the establishment of (quantitative) structure–activity relationships, the development of novel in vitro toxicity screening tests and the elaboration of prioritization strategies.

Development of AOPs ideally complies with OECD guidelines. There is currently one AOP (34) on "LXR activation leading to hepatic steatosis" that is relevant for the participants as a case-study. The participants will go through the diffferent novel hepatic systems of the liver (and their molecular components) linked to the relevant AOPs at different stages of development.

Date:
June 23 - 24, 2016

Venue:
Biopredic International - Parc d’activité de la Bretèche Bâtiment A4,
Saint Grégoire, France

Talk:
June 23,
14.30 – 15.30 Lecture: Why 3D cell culture?
by Dr. Katrin Rössger of InSphero

Hands-on Training:
June 23, 16.30 – 18.00 Hands-on-Training: 3D Cell-based assay
by Dr. Katrin Rössger of InSphero

Find out more aobut the CAAT "Hepatotoxicity Testing based on Adverse Outcome Pathways" Training

23. - 25.08.2016 - Biointerfaces International 2016

cosmetica xirrus

Date:
August 23 - 25, 2016

Venue:
University of Zurich
Zurich, Switzerland

Talk:
Talk "From 3D cell cultures to drug screening and diagnostics"
Wednesday, August 24, 10:40 by Melanie Aregger of InSphero

Find out more aobut the Biointrfaces International Conference 2016

24. - 27.08.2016 - EUSAAT 2016 - 17th Annual Congress of EUSAAT

Banner Linz 2016 EUSAAT 2016 160218 vkl800x358 web

Date:
August 24 - 27, 2016

Venue:
Johannes Kepler University (JKU) Linz
Linz, Austria

Booth:
coming soon

Talk:
Talk "Increasing biological relevance in vitro: From single microtissues to micro-physiological systems "
 by Dr Jens Kelm of InSphero

Talk "Automation-compatible EST assay"
by Dr Simon Ströbel of InSphero

Practical Training Course

Use of ready-made 3D model systems by Dr. Jens Kelm of InSphero
In vitro models have become more complex over the past years to better reflect in vivo structure and function. However, the more complex in vitro models become the more difficult it will be to ensure that the models are standardized and display comparable characteristics. A good example for successful introduction of standardized, ready-to-use 3D in vitro models are skin and epithelial models. Due to better standardization, in vitro models of the skin and epithelium are only rarely produced by the researchers themselves but rather bought from regular suppliers. Next to skin and epithelial models only a few other tissue types are available as ready-to-use organotypic tissue culture models. Adding to the portfolio of available organotypic models systems, we will introduce 3D liver and islet microtissue platforms and how these models can be used to assess DILI and DIII. Both models are composed of primary cells and reflect tissue-like cell composition. Based on an increased in vitro lifetime of both organ models, standardized in vitro assays will be showcased to assess toxicity over a 14-day time frame.

 

Find out more aobut the EUSAAT 2016 Congress

26. - 29.06.2016 - CLINAM 9/2016

Clinam

Clinical Nanomedicine and Targeted Medicine, Enabling Technologies for Personalized Medicine

Date:
June 26 - 29, 2016

Venue:
Basel, Switzerland

Talk:
Sunday, June 26, 14:20 "Stem cell-based microtissue engineering for drug development"
 Dr. Wolfgang Moritz of InSphero

 

Find out more about CLINAM 9/2016

27. - 29.06.2016 - High Content Screening Conference

header HCS banner 4

This Conference will gather researchers, academics and industry professionals working in High-Content Screening to explore the latest advances and emerging technologies in the field. Hot topics include novel organisms, novel markers, new essays, novel microscopy techniques, image analysis and statistics.

Date:
June 27 - 29, 2016

Venue:
Max Planck Institute of Molecular Cell Biology and Genetics
Dresden, Germany

Talk:
Snapshot presentation "Quantification of efflux transporter activity in 3D Human Liver Microtissues"
Tuesday, June 28 by Dr. Andrea Lindemann of InSphero

 

Find out more aobut the SLAS HC

02. - 05.10.2016 - EACR: Goodbye Flat Biology: Models, Mechanisms and Microenvironment

header EACR2

After the success of the first ‘Goodbye Flat Biology’ meeting in 2014, the EACR is delighted to announce the second conference in the series: ‘Goodbye Flat Biology: Models, Mechanisms and Microenvironment’. This conference will focus on the applications of state-of-the-art 3D culture and tissue engineering technologies to address specific scientific questions ranging from basic tumour biology to more preclinical and translational research. The conference will be opened by Peter Friedl, a pioneer of multifocal microscopy to study cell migration and invasion, and concluded by Valerie Weaver, Director of the Center for Bioengineering and Tissue Regeneration.

Date:
Ocotber 2-5, 2016

Venue:
Harnack House - The Conference Venue of the Max Planck Society
Ihnenstr. 16-20, 14195 Berlin, Germany

Poster:

1) "In vitro assessment of tumor relapse in a 3D tumor microtissue model"
2) "Multiparametric tumor microtissue-based phenotypic compound classification"

Register here

More information:
www.eacr.org

28.09. - 01.10.2015 - SPS 15th Annual Meeting

 

Safety Pharmacology Society Who Attends the Annual Meeting?

Date:

28 September - 01 October, 2015

Venue:
Prague Congress Centre, Czech Republic

Presentation/ Poster:

joint work of InSphero & Clyde Bioscience
Characterization of the physiology and cardiotoxicity of cardiac 3D microtissues of hiPSC-derived Cardiomyocytes (hiPSC-CMs)

More information about the SPS 15th Annual MeetingPS 15th Annual Meeting

 

 
 

22. - 24.09.2015 - MipTec

 2015 08 18 13 01 37 Exhibition

 
MipTec - The International Life Science Exhibition 2015

It is an exciting time for life science research, as many fundamental discoveries in laboratories around the world have transitioned into break through applications for human health. At the Basel Life Science Week and the MipTec exhibition, inspired people will be brought together in cross disciplinary forums to ensure research applied to human health remains at the cutting edge.
he 2015 science programme will have multiple streams with leading science experts covering advances in Aging, Cell signaling, Medicinal chemistry, Synergy of combination drug therapies, Next Generation Sequencing applications, Information management, Stem cells, Peptide therapies, GPCRs and Translational Medicine. In addition, the annual MipTec Industry Exhibition, networking socials, lunch hour symposia, poster presentations, and pre-conference workshops will allow for enhanced learning.

Date:
22 - 24 September, 2015

Venue:
Congress Center Basel, Basel, Switzerland

Presentation:
Making the Jump - How to Start Business in the USA 
by Dr. Jan Lichtenberg

Industry Symposium, Room 3
September 22, 2015 at 12:30 - 13:30

More information about MipTec

 

13. - 16.09.2015 - EUROTOX

 eurotox201511

 
51st Congress of the European Societies of Toxicology

Bridging Science for Safety

EUROTOX Annual Congress certainly represents a unique occasion to participate in the most important regular event of Toxicology in Europe and one of the most relevant in the world. It provides excellent opportunities for meeting delegates from all over the world, and is a privileged stage for exchanging ideas and experiences among colleagues and friends, establishing and reinforcing scientific networks, and learning the forefront scientific developments from distinguished scientists, opening minds for new concepts and paradigms in Toxicology and related sciences.

Date:
13 - 16 September, 2015

Venue:
Alfândega Congress Centre Porto

Booth:

Meet InSphero at booth #14
Learn more about our 3D InSight™ Microtissues and Standard Services for more biologically relevant toxicity testing.

Looking to move your toxicity testing into 3D?  Now is the time to evaluate InSphero human liver microtissues so you can include them in your 2016 budget.  Purchase a 3D Complete™ Human Liver Microtissue Kit for evaluation by December 31, 2015 and save 30%. 
Download the promo flyer.

Workshop:

Functional intravital imaging of hepatotoxicity: comparing intact livers to 3D in vitro systems
WS04-3/ Monday, September 14: 4:00 - 6:00 PM

Posters:

Transmembrane potential measurements of 3D cardiac microtissues derived from iPS cardiomyocytes
Poster#P07-031/ Monday, September 14: 2:00 - 3:30 PM

In-depth characterization of 3D human liver microtissues by transcriptomic, proteomic and functional analysis
Poster #P07-035/ Monday, September 14: 2:00 - 3:30 PM

Pro-drug activiation in dynamic microphysiological fluidic systems interconnecting liver and tumor microtissues
Poster #P07-020/ Monday, September 14: 2:00 - 3:30 PM
Session "Emerging in Vitro Models"

Standardized Rat and Human Microislets for Diabetes Research and Drug Safety Assessment
Poster #P12-032/ Tuesday, September 15: 3:00 - 4:30 PM
Session "Organ Toxicities"

 

More information about EUROTOX

11.05.2015 - InSphero & Promega User Group Seminar, Munich, Germany

Promega WS Munich

InSphero & Promega User Group Seminar

3D Cell Cultue Model Systems & Cell-based Assays for Use with 3D Cultures.

Location:

ZB Martinsried 
Zentralgebäude Konferenzraum
Kubus 1 und 2
Am Klopferspitz 19
82152 Planegg-Martinsried

Date and Time:

Monday, May 11, 2015
14:30 - 16:30

Speakers:

Dr. Simon Messner, Product Manager Microtissues

Dr. Terry Riss, Global Strategic Marketing Manager Cell Helth of Promega

Register here

InSphero

Logo mit Tagline C35 M0 Y100 K39 300dpi

Microtissue models for drug de-risking

 

Cell-based assays have become an inherent part in drug discovery and
development to predict the in vivo response to biologicals and chemicals. The
better the in vivo system reflects the in vivo situation the better can a drug
being qualified. However, to gain the maximum benefit of in vivo cell cultures
for de-risking compounds cells have to be maintained in a format which reflects
in vivo cellular functionality, either animal or human, as closely as possible.
Organotypic 3D cell culture models can impact cell-based assays throughout
the drug development chain, including: (i) drug target validation, (ii) primary
and secondary screening set up’s, (iii) lead optimization and (iv) toxicological
profiling. With this objective, microtissue engineering strategies are being
exploited to further improve the predictive power of cell-based assays. Here
we present case studies how organotypic microtissue models can be applied
for target discovery, efficacy testing and toxicological profiling.

 

Promega

promega

Application of in vitro assays to measure cellular response in 3D cell cultures

 The use of 3D cell cultures continues to emerge as improved in vitro models
that are more physiologically relevant and more predictive of cytotoxic
events in whole animals. Multicellular 3D culture systems containing more
than one cell type and exhibiting formation of a complex extracellular
matrix provide a challenge for assay chemistries originally designed for
measuring events from monolayers of cells. Critical factors to consider for
each model system and cell type include effective penetration of detection
reagents and/or complete lysis of microtissue structures using combinations
of detergent and physical disruption. We will present the approach used to
verify performance of the bioluminescent ATP detection assay for measuring
cell viability, a caspase assay for detecting apoptosis, and cell stress reporter
assays to detect mechanisms leading to cytotoxicity. Recommendations for
factors to consider when verifying performance of cell health assays on 3D
culture models will also be presented.

 

 

 

 

05. - 06.05.2015 - 2nd Tissue Models & Phenotypic Screening, GTC Conference

2015 04 27 10 31 59 2nd Tissue Models Phenotypic Screening Agenda

 3D Models for Drug Safety Testing and Screening

Over the years, three-dimensional (3D) models have become more favored over two-dimensional models (2D) because they better mimic the in vivo environment. Though 3D models have the potential to reduce failure in early stage drug discovery, there are still many questions to be answered: What are the gaps that still exist between 3D and 2D models? How will we conduct research to fill those gaps and what technological developments are needed?

 Get some answers and join the talk of 
Dr. Jens Kelm, Chief Scientific Officer and Co-Founder of InSphero AG


Date & Time:
05 May, 2015 at 14:10

Topic: 
Microtissues meet Microfludic: a Body on a Chip Platform Technology Based on a Multiparallel Standard SBS Layout

More information 

Click here to register for the 2nd Tissue Models & Phenotypic Screening Conference

04.05.2015 - InSphero & Promega User Group Seminar, Berlin, Germany

Promega WS Berlin

InSphero & Promega User Group Seminar

3D Cell Cultue Model Systems & Cell-based Assays for Use with 3D Cultures.

Location: BEST WESTERN PREMIER Hotel, MOA Berlin, MOA4 - 1. OG, Stephanstrasse 41, 10559 Berlin

Date and Time: Monday, May 4, 2015, 14:00 - 16:00

Speakers:

Dr. Jens Kelm, Chief Scientific Officer and Co-Founder of InSphero

Dr. Terry Riss, Global Strategic Marketing Manager Cell Health of Promega

Register here!

InSphero

Logo mit Tagline C35 M0 Y100 K39 300dpi

Microtissue models for drug de-risking

 

Cell-based assays have become an inherent part in drug discovery and development to predict the in vivo response to biologicals and chemicals. The better the in vivo system reflects the in vivo situation the better can a drug being qualified. However, to gain the maximum benefit of in vivo cell cultures for de-risking compounds cells have to be maintained in a format which reflects in vivo cellular functionality, either animal or human, as closely as possible. Organotypic 3D cell culture models can impact cell-based assays throughout the drug development chain, including: (i) drug target validation, (ii) primary and secondary screening set up’s, (iii) lead optimization and (iv) toxicological profiling. With this objective, microtissue engineering strategies are being exploited to further improve the predictive power of cell-based assays. Here we present case studies how organotypic microtissue models can be applied for target discovery, efficacy testing and toxicological profiling. 

Promega

promega

Application of in vitro assays to measure cellular response in 3D cell cultures

The use of 3D cell cultures continues to emerge as improved in vitro models that are more physiologically relevant and more predictive of cytotoxic events in whole animals. Multicellular 3D culture systems containing more than one cell type and exhibiting formation of a complex extracellular matrix provide a challenge for assay chemistries originally designed for measuring events from monolayers of cells. Critical factors to consider for each model system and cell type include effective penetration of detection reagents and/or complete lysis of microtissue structures using combinations of detergent and physical disruption. We will present the approach used to verify performance of the bioluminescent ATP detection assay for measuring cell viability, a caspase assay for detecting apoptosis, and cell stress reporter assays to detect mechanisms leading to cytotoxicity. Recommendations for factors to consider when verifying performance of cell health assays on 3D culture models will also be presented.  

 

 

 

18.04.-22.04.2015 - AACR 2015 - Philadelphia, PA, USA

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Meet InSphero at the 2015 AACR Annual Meeting - Booth #1351

Meet the InSphero team in Philadelphia at the AACR Annual Meeting being held at the Pennsylvania Convention Center.  This year's meeting offers plenty of opportunities to learn more about our industry-leading 3D microtissue models, cell based assays, and imaging solutions for more biologically relevant safety and efficacy testing, including: 

  • Discover how the InSphero GravityTRAPTM ULA Plate (Coming Soon) and GravityPLUSTM 3D Culture and Assay Platform facilitate high-throughput, automation-compatible production and assessment of scaffold-free 3D spheroids
  • Learn how the SCREEN Cell3iMager enables fast, label-free phenotypic screening of 3D spheroid growth and morphology
  • Use our 3D InSightTM Tumor-stromal co-culture models, Liver Microtissues, and Pancreatic Microislets, to deliver more predictive, biologically relevant in vitro assessment of efficacy, toxicity and disease modeling. 
  • Learn how we've partnered with industy-leading cell-based assay and imaging providers to develop 3D-optimized protocols to help you make the most of your 3D cell culture
  • See how our 3D experts can customize a contract research project to meet your needs

 

Scaffold-free 3D Cell Culture

Gravity PLUS 3d cell culture kits

3D cell culture made easy

SCREEN Cell3iMager

Cell3iMager

 Rapidly monitor spheroid growth

Tumor Microtissues

3D InSight microtissues drug discovery

Assay-ready tumor spheroid and co-culture models

Poster Presentations

Development of a novel 3D cancer model by cultivation of malignant effusions in a 3D cell culture system
(presented by Dr. Arno Amann, Medical University Innsbruck)
Session: 3D Cultures and Tissue/Organoid Models
Abstract #316, Section #14, Poster #15
Sunday, April 19: 1:00 PM - 5:00 PM

Differences in RNA expression and chemosensitivity in 2D versus 3D non-small-cell lung cancer cultures
(presented by Dr. Gabriele Gamerith, Medical University Innsbruck)
Session: 3D Cultures and Tissue/Organoid Models
Abstract #326, Secton #14, Poster #25
Sunday, April 19: 1:00 PM - 5:00 PM

Three-dimensional microtissues as phenotypic screening model to identify radiation modifiers for breast cancer
(presented by Dr. Natasa Anastasov of the Helmholz Zentrum München)
Session: Translational Radiation Oncology Session
Abstract #1810, Section #33, Poster #23
Monday, April 20: 8:00 AM - 12:00 PM

Generation of 3D-microtissues suitable for drug screening with lentivirally GFP-labelled CD44+CD24- breast cancer cells enriched by irradiation
(presented by Dr. Ines Höfig of the Helmholz Zentrum München)
Session: Cancer Stem Cell Identification
Abstract #1408, Section #15, Poster #20
Monday, April 20: 08:00 AM - 12:00 PM

Win a $300 AACR Meeting Travel Grant!

SOT ObstacleCourse

Maneuver our robotic 3D tumor "oncosphere" through the oncology obstacle course, and you could win a $300 travel award to an upcoming AACR meeting, or great discounts on 3D cell culture products.  Join us at booth 1351 for your chance to win!

Register at the official meeting site.

This email address is being protected from spambots. You need JavaScript enabled to view it.This email address is being protected from spambots. You need JavaScript enabled to view it.

 

11. - 12.05.2015 - 2015 BMS R&D Symposium

RD FINAL 01

 Meet InSphero at Booth #524

 Join us at the 2015 BMS R&D Symposium to learn more about how InSphero 3D InSight™ Microtissue models and 3D InSight™ Services can bring greater biological relevance to your toxicity and efficacy testing.  Featured products and services include:

Date:
11 - 12 May, 2015

Venue:
DoubleTree Hotel and Garden State Exhibit Centre, Somerset NJ, USA

Meet InSphero at booth #524

More information

14.05.2015 - MSMR/NJABR 3Rs Sharing Conference

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Meet InSphero and Join our Afternoon Workshop on 3D Model Systems

Hosted by the New Jersey Association for Biomedical Research and the Massachusetts Society for Medical Research, in partnership with the American Association of Laboratory Animal Science (AALAS), the International Consortium for Quality & Innovation in Pharmaceutical Development (IQ Consortium).

Engage with experts who are developing innovative strategies to move science forward at the 3Rs Sharing Conference IV.

Date:
14 May, 2015

Venue:
Boston Marriott -  Newton MA, USA

Afternoon Breakout Session (Replacement Track) Hosted by InSphero

State-of-the-art organotypic 3D microtissue models for more predictive in vitro toxicity and efficacy testing

Randy Strube and Stewart Hunt, InSphero Inc.


More information

21.05.2015 - InSphero User Group Meeting, Zurich, Switzerland

UGM ZH Banner

2015 InSphero User Group Meeting, Zurich

Join us Thursday, May 21 for a day of informative 3D cell culture presentations at InSphero's 5th annual Zurich User Group Meeting, being held at the Technopark Zurich. We have prepared an exciting full-day agenda that brings together international experts in toxicology and efficacy testing using 3D in vitro systems. Secure your seat at this great educational and networking opportunity – you won't want to miss it!

  • Full-day agenda covering Toxicology and Oncology applications
  • Live demo of GravityPLUSTM and the new GravityTRAPTM cell culture platforms
  • Networking lunch and post-event reception included
  • Great guest-speakers from Sanofi-Aventis, Helmholz-Institute Munich, ETH Zurich and many more

Location: Technopark Zurich, Technoparkstrasse 1, 8005 Zurich, Switzerland

Date and Time: Thursday, May 21, 2015, 08:30 - 17:30

Agenda:

 08:30 - 09:00       Welcome Reception and Introduction by Dr. Jan Lichtenberg, CEO InSphero AG, Switzerland

09:00 – 09:30      3D InSightTM Liver Microtissues by Dr. Simon Messner, InSphero AG, Switzerland

09:30 – 10:00      3D InSightTM Services Overview by Dr. Johannes Haugstetter, InSphero AG, Switzerland

10:00 – 10:30      Testing Biologicals Using 3D Microtissue Models by Dr. Jens Kelm, InSphero AG, Switzerland

10:30 – 11:00      Coffee Break incl. Live Demonstration

11:00 – 11:30      Compound Classification Strategies Using Homo- and Heterotypic Tumor Microtissues by Zoe Weydert, 
                               Master of Science at Zurich University of Applied Sciences (ZHAW)


11:30 – 12:00      Cell-Based Assays for more than Monolayers by Dr. Reka Nagy, Promega AG, Switzerland

12:00 – 13:00      Networking Lunch

13:00 – 13:30      Global Proteonic Profiling of 3D Human Liver Microtissuesby Dr. Claudia Escher, 
                                Biognosys AG, Switzerland


13:30 – 14:00      Imaging Bile Canaliculi in 3D InSightTM Human Liver Microtissues Using the Opera PhenixTM High 
                               Content Screening System by Dr. James Hutt, PerkinElmer, United Kingdom

14:00 – 14:30      Our Body on a Chip byDr Olivier Frey, ETH Zurich, Switzerland

14:30 – 15:00      Coffee Break incl. Live Demonstration

15:00 – 15:30      Pancreatic Microislet Model for Glucose- Stimulated Insulin Secretion Assay  
                            
by Dr. Kristin Breitschopf, Sanofi-AventisDeutschland GmbH


15:30 – 16:00      3D Microtissues Are Relevant Models to Investigate Target Genes and Therapeutic Approaches for Breast 
                               Cancer by Dr. Nataša Anastasov, Helmholz Center Munich, Germany 


16:00 – 17:30      Wrap Up & Networking Reception by Dr. Jan Lichtenberg, CEO InSphero AG, Switzerland

02. - 03.06.2015 - Merck Technology Symposium 2015

2015 Merck Tech Banner Resized

 Celebrating Success, Building for the Future

The symposium provides a great networking platform covering the scientific areas of in vivo & in vitro science, drug delivery & formulation, biomarker & point of care diagnostics, clinical and information science as well as manufacturing technologies and many more. 

Date:
02 - 03 June, 2015

Venue:
DoubleTree Hotel and Garden State Exhibit Centre, Somerset NJ, USA

Tabletop:
Meet InSphero at tabletop #35

More information

14. - 16.09.2015 - 11th Annual APA Meeting

 apa logo

51th Congress of the European Societies of Toxicology

Date:
14 - 16 September, 2015

Venue:
Hyatt Regency Cambridge, MA, USA

Poster/ Presentations:
Coming soon

More information about the APA Meetinghe APA Meeting

20. - 23.09.2015 - EUSAAT Congress

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19th European Congress on Alternatives to Animal Testing

Date:
20 - 23 September, 2015

Venue:
Johannes Kepler University (JKU), Linz, Austria


Booth:
Meet InSphero as exhibitor (booth # coming soon)

Poster:

iPS-derived Human 3D Cardiac Microtissues to Assess Cardiac Toxicity
by Dr. Jens Kelm
Poster Session 1 - Monday, 20. September 2015, 17:00 - 19:00

Omics Analysis of Human Liver Microtissues Grown over 4 Weeks: Implications for Studies of Liver Functions
by Dr. Jens Kelm
Poster Session 1 - Monday, 20. September 2015, 17:00 - 19:00

Talk:

Pro-drug Activation in a Dynamic Microfluidic Systems Interconnecting Liver and Tumor Microtissues
by Dr. Jens Kelm
Scientific Session - Monday, 20. September 2015, 09:00 - 10:30

More information about EUSAAT

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15. - 16.06.2015 - Sanofi-Genzyme Cellular Assay Forum

Sanofi Cellular Assay Forum Resized

 Develop a New Generation of Assays

Over years it was a common thought that it was adequate to construct target-specific cellular assays to find hits and drive lead optimization. These assays were often relatively inexpensive and robust. They were not, however, always physiologically relevant or predictive of activity in patients.
How do we make assays that are predictive of human disease yet robust enough to provide reliable data for lead optimization?
The Sanofi-Genzyme Cellular Assay Forum will explore ways to develop this new generation of assays. 

Date:
15 - 16 June, 2015

Venue:
The Conference Centre at Waltham Woods - Waltham, WA, USA

Booth:
Meet InSphero at Table #102

Presentation:
State of the art 3D cardiac and neural microtissue models for toxicity testing and disease modeling

Dr. Jan Lichtenberg
CEO and co-founder InSphero AG

In vivo animal models are primarily employed to assess cardio-and neurotoxic effects of chemicals and potential candidate compounds in drug development, while in vitro testing is limited to HTS compatible, low complexity 2D cultures of primary cells or cell lines, or testing on more sophisticated low throughput explant cultures. 3D cardiac and neuronal microtissues not only represent more biologically relevant model systems in which to investigate drug-related toxicity, but also hold promise for the development and assessment of more organotypic in vitro disease models using genetically modified cells and/or compounds to induce a diseased phenotype. This talk will cover InSphero's 3D InSight™ Cardiac and Neuronal Microtissues, with emphasis on their structural and functional characterization, and downstream endpoint compatibility afforded by the scaffold-free 3D culture platform employed in their production.


More information 

30.09. - 01.10.2015 BioConference Live Cancer Research & Oncology

 926x185 BCL 2015 Cancer

 
Interactive Online Conference allowing Attendees to engage One-on-One with Experts 

Cancer research is one of the largest fields in science today. Many advances have been made over the last few years that have enabled cancer patients to overcome the disease and drastically decrease mortality rates. Advances in technology have also helped propel cancer research exponentially forward. Nanotechnology and diagnostic techniques offer new tools to work towards cures and early treatment.

Date:
30 September - 01 October, 2015

Venue:
Online

Visit our virtual booth

 

More information about the BioConferencethe BioConference

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22.10.2015 - TEDD Annual Meeting 2015

 
TEDD Quote Jens 

TEDD Annual Meeting 2015 - Moving 3D Cell Cultures from Bench to Practice

In 2010 the co-founders ZHAW and InSphero AG launched the TEDD competence centre with funding from the Gebert-Rüf Foundation (BREF 2010). In the past 5 years the TEDD network has established itself and successfully promoted 3D cell culture activities. Company visits, workshops and symposia with both industrial and academic partners have been organized and several network projects started using the platform. Currently, 8 network projects funded by the Swiss government are running successfully.

Three-dimensional (3D) cell culture technology is one of the fastest growing experimental approaches in the life sciences. The 3D cell culture market was valued at $438.1 million in 2013 and is expected to grow to about $2.2 billion in 2019 (BCC Research Biotechnology Report). The technology has progressed to the extent that cell-based in vitro assays are now being used throughout the drug discovery and development chain. A major challenge, however, is the translation of in vitro assays to the corresponding in vivo outcomes. Physiological relevance is a key parameter to improve the predictive power of cell-based assays, and the more we can reflect tissue architecture, composition and function, the more predicitve in vitro assays will become. For this reason 3D cell culture needs to enter its next phase of development: Technology maturation, optimization of assays, protocols and kits, and compatibility with automated lab equipment. The goal is the implementation of easy-to-handle biomimetic tissue constructs that simulate the in vivo condition in a reproducible and reliable way.

Date:
22 October, 2015

Venue:
Kompetenzentrum TEDD, Institut für Chemie und Biologische Chemie, ZHAW Life Science and Facility Management
Wädenswil, Switzerland

Booth:
coming soon

More information about the TEDD Annual Meeting 2015 

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15. - 18.06.2015 - 2015 Bio International Conference

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 Get New Insights, Knowledge and Partnerships

The 2015 Bio International Convention is once more the world's largest biotechnology gatherings to form new partnerships and evaluate emerging technologies. BIO covers the spectrum of life science innovations and applications areas. Drug discovery, biomanufacturing, genomics, biofuels, nanotechnology and cell therapy are just a few of the industries represented at the BIO International Convention.

Date:
15 - 18 June, 2015

Venue:
Pennsylvania Convention Center, 1101 Arch St, Philadelphia, PA 19107

Booth:
Meet InSphero at Booth #801

More information

05. - 09.11.2015 - AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

 AACR 

The premier international meeting featuring novel cancer therapeutics.
 

The meeting conference will bring together an estimated 3,000 academics, scientists, and pharmaceutical industry representatives from across the globe to discuss innovations in drug development, target selection, and the impact of new discoveries in molecular biology. During the last few years, numerous innovative agents have been discovered as a result of tremendous developments in the understanding of the molecular basis of cancer. Further clinical progress in cancer treatment will be accomplished mainly through the conduct of translational research projects, efficient new drug development and the execution of large, prospective, randomized, multicenter cancer clinical trials. This requires a joint and global approach, and early and optimal exchange of information.     

 

Date:
05. - 09. November, 2015

Venue:
Hynes Convention Center, Boston, MA, USA

Booth:
Visit us at Booth #311

More information about the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

09. - 11.11.2015 - 3rd Annual FAST Congress

 FAST 

- 3D Cell Culture: Organoid, Spheroid, and Organ-on-a-Chip Models
- Phenotypic Drug Discovery
- Screening and Functional Analysis of 3D Models
 

Physiologically relevant complex cellular models that are predictive of human response are needed to improve drug discovery and toxicity testing in order to reduce costly late-stage attrition. 3D cell models have the ability to create tissue-specific structure and function, allowing more predictive in vitro assays. Cambridge Healthtech Institute’s Inaugural 3D Cell Culture meeting will cover the latest advances in tissue engineering and assay development for organoid, spheroid, and organ-on-a-chip models, including their applications in efficacy and safety screening, functional analysis, and compound de-risking. Coverage will include primary and stem cell models, complex co-culture cell models, tumor spheroid models, novel organ-on-a-chip models, and more.

Phenotypic screening (A.K.A. classical pharmacology) has been historically used in drug discovery. While technological developments have made the prevalence of target-based screening more popular, statistical analysis shows that a disproportionate number of first-in-class drugs with novel mechanisms of action come from phenotypic screening. Cambridge Healthtech Institute’s 3rd Annual Phenotypic Drug Discovery meeting will address the advantages of phenotypic screening vs. target-based screening, and focus on assay development, selection of physiologically relevant models, and subsequent target identification and validation.

While more informative than cell-free biochemical assays, monolayer or suspension cell culture HTS assays still fail to accurately reflect the human cellular microenvironment. There is a need for physiologically relevant cellular models for drug screening and functional analysis that provide high predictive value for clinical efficacy and safety of compounds. The 3-dimensional cell culture models mimic the human tissue microenvironment and provide more accurate information for compound and target selection, thereby reducing late-stage attrition. Cambridge Healthtech Institute’s 3rd Annual Screening and Functional Analysis of 3D Models meeting will explore the use of 3D models to profile compound action and predict toxicity and efficacy. The meeting will cover assay development using 3D cellular models, high-content analysis and imaging of 3D models, and applications of screening 3D models for compound profiling and target discovery/validation.

 

Date:
09. - 11. November, 2015

Venue:
Renaissance Waterfront Hotel, Boston, MA, USA

Booth:
Visit us at Booth #7

 

More information about the FAST Congress 2015

10. - 11.11.2015 - IVTS 2015

 IVTS 

Championing in vitro and computational toxicology
 

The meeting will bring together scientists from across academia and industry and regulators to discuss the latest advances, challenges and opportunities in applying in vitro approaches in the areas of hepatotoxicity, inhalation toxicology, developmental and reproductive toxicology and neurotoxicology.

 

Date:
10. - 11. November, 2015

Venue:
Jurys Inn, Birmingham, UK

Booth:
coming soon

Posters:
coming soon

 

More information about the IVTS 2015

22. - 25.06.2015 - ISSX

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13th European Meeting of the International Society for the Study of Xenobiotics (ISSX)

The Meeting Organising Committee has designed a programme to address key research topics including: PBPK Modelling, Stem Cell Technology Developments and their Application to Drug Metabolism and Drug Safety, the Role of Drug Transporters, Epigenomics in Drug Metabolism and Disease, Mass Spectrometry of Small Molecules, and much more. The meeting additionally will feature a wide range of contemporary research topics in the form of poster presentations as well as industry-sponsored educational sessions each morning prior to the general meeting. Complementing the meeting, top suppliers to the scientific community will present their products and services during the meeting exhibition.

Date:
22.- 25. June, 2015

Venue:
University of Strathclyde, Glasgow, Scotland

Booth:
Meet InSphero at booth #204

Poster:

Screening for Hepatobiliary Transporter Inhibition in 3D Human Liver Microtissues by Confocal Imaging

Poster #P165, Session 2
Wednesday, June 24 12:30 - 13:00
Presented by Dr. Simon Messner, InSphero AG 

Learn more about confocal screening of hepatobiliary transporter activity in 3D InSightTM Liver Microtissues:

GEN Tutorial

More informationabout ISSX

08.02.-10.02.2015 - SLAS 2015 - Washington, DC, USA

Are you screening in relevant 3D model systems?

Meet InSphero at SLAS 2015 - Booth #751

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Meet the InSphero team in Washington, DC at the 4th Annual SLAS Conference and Exhibition! Visit us and our colleagues from SCREEN Holdings Co., Ltd. at booth #751 to learn more about automation-friendly 3D cell culture, assay and imaging technologies, including: 

  • Discover how the InSphero GravityPLUSTM 3D cell culture and assay platform facilitates high-throughput, automation-compatible production and assessment of scaffold-free 3D spheroids
  • Learn how the SCREEN Cell3iMager enables fast, label-free phenotypic screening of 3D spheroids
  • Use our 3D InSightTM Liver Microtissues, Pancreatic Microislets, and Tumor-stromal co-culture models to deliver more predictive, biologically relevant in vitro assessment of toxicity, efficacy and disease modeling
  • Learn how to adapt industry leading cell-based assays to make the most of 3D model systems
  • See how our 3D experts can customize a contract research project to meet your needs

 

Win with InSphero! 

Take a break from the posters and talks, and enjoy two ways to win with InSphero at SLAS 2015. 

  • Play our "Hit your screening target" game!  Pick the right spheroids, and you could win 3D InSightTM Liver Microtissues, GravityPLUSTM plates, or 3D InSightTM Cytotoxicity Assay Kits.  Everyone who plays wins a 2015 desktop calendar
  • Bring your Promega stamp card to our booth for validation to be entered into the drawing for some great prizes! 

 

Short Course - Sunday, February 8

8:30 AM - 4:30 PM EST - 3D Cell-Based Assays for Drug De-Risking

The continually rising numbers of compound failures and increasing costs of drug and substance development are fostering the use of biologically more complex cell models. Physiological relevance is a key parameter to improve the predictive power of cell-based assays. The course covers advanced 3D cell culture technologies and their use in substance testing.

Instructors include InSphero's Dr. Jens M. Kelm, Dr. Ursula Fraf-Hausner of the University of Applied Sciences Zurich, Switzerland, Dr. Terry Riss from Promega, and Dr. Ty C. Voss of Perkin Elmer

 

Podium Presentation - Tuesday, February 10

12:00 - 12:30 PM EST (Room 151A) - Microtissues Meet Microfluidics: A Body on a Chip Platform Technology Based on a Highly Parallel Standard SBS Layout

Dr. Jens M. Kelm, InSphero AG

View our latest Body on a Chip publications here. 

 

Exhibitor Tutorial - Monday, February 9

2:00 - 2:45 PM EST (Room 159AB) - 3D cell based assays and label-free testing methods for safety and efficacy testing..

InSphero’s assay-ready 3D InSight™ microtissues provide biologically more relevant model systems and rapid solutions for incorporating 3D organotypic models into drug efficacy and toxicity screening workflows. This tutorial addresses combined use of 3D microtissues and cell-based assays with high-throughput plate readers, as well as rapid assessment of tumor spheroid growth using the SCREEN Cell3iMager. Key aspects comprise:

  • 3D microtissue models for target validation
  • 3D microtissue models for efficacy testing
  • 3D microtissue models for safety testing

Dr. Jens M. Kelm, InSphero AG

Poster Presentation - Monday, February 9

1:00 - 3:00 PM EST (Poster #1048) - Measuring live cells and dead cells in real time for days using a plate reader: subsequent multiplexing to improve efficiency and reproducibility.

Presented by Terry L. Riss, Promega Corporation

View the online meeting program.. 

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05.03.-08.03.2015 - ENDO 2015 - San Diego, CA, USA

Meet InSphero at ENDO 2015 - Booth #1830

Meet the InSphero team in San Diego at the 2015 Annual Meeting of the Endocrine Society and ENDO Expo.  Visit our poster presentation or Expo booth (#1830) to learn more about our solutions for upgrading your model system to 3D, including:  

  • Discover 3D InSightTM Human and Rat Pancreatic Microislets, our long-lived, standardized islet microtissue models for diabetes and metabolism research
  • Explore our Human, Rat, and HepG2 Liver Microtissues, offering a long-lived, organotypic, and metabolically competent in vitro model system for more predictive toxicity, efficacy and disease modeling
  • Learn about our 3D cardiac, neuronal and other emerging model systems
  • View our GravityPLUSTM and GravityTRAPTM platform for high-efficiency production and assay of scaffold-free, 3D cell culture   
  • Learn how we're partnering with industry leading cell based assay, proteomics, and imaging companies to ensure you can make the most of our 3D model systems
  • See how our 3D experts can customize a contract research project to meet your needs

 

Poster Presentation

Standardized Rat and Human Pancreatic Microislets for Diabetes Research and Drug Safety Assessment
Dr. Wolfgang Moritz

Poster Board LBS-106
Saturday, March 7, 2015: 1:00 PM-3:00 PM
Hall D-F, Diabetes

Register at the official meeting site.

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11.03.- 12.03.2015 - Bayern Innovativ Forum Life Science 2015 - Munich, Germany

Discover 3D testing made simple.

Meet InSphero at Forum Life Science 2015

Meet the InSphero team in Munich, Germany at the Bayern Innovativ 4th Annual SLAS Conference and Exhibition! Learn how InSphero 3D cell culture technology, assay-ready microtissues, and 3D-focused screening services have simplified safety and efficacy testing, including: 

  • Discover how the InSphero GravityPLUSTM 3D cell culture and assay platform facilitates high-throughput, automation-compatible production and assessment of scaffold-free 3D spheroids
  • Learn how the SCREEN Cell3iMager enables fast, label-free phenotypic screening of 3D spheroids
  • Use our 3D InSightTM Liver Microtissues, Pancreatic Microislets, and Tumor-stromal co-culture models to deliver more predictive, biologically relevant in vitro assessment of toxicity, efficacy and disease modeling
  • Learn how to adapt industry leading cell-based assays to make the most of 3D model systems
  • See how our 3D experts can customize a contract research project to meet your needs

 

Poster Presentation

P15 - 3D multi-cell type human liver microtissues for safety assessment

Dr. Jens M. Kelm, InSphero AG

 

InSphero User Group Meeting - Friday, 13 March (08:30 - 13:30)

InSphero will be hosting our Munich User Group Meeting on Friday, 13 March in conjunction with the Forum Life Science 2015 event.  Please click here to view the agenda and to register.  Stay an extra day and take advantage of this excellent learning opportunity!

View the online meeting program and register for Forum Life Science 2015.

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13.03.2015 - InSphero User Group Meeting, Munich, Germany

Zuverlässige Substanztestung in 3D-Zellkultursystemen

Predictive Drug De-risking with 3D Cell-based Assays

InSphero's next user group meeting will be held in Munich, Germany on Friday, 13 March in conjunction with the Bayern Innovativ Forum Life Science 2015.  The half-day event will be held on Friday morning at the Technische Universitat Munchen - Garching, and will bring together experts in efficacy and toxicology testing with 3D in vitro systems. This free event is a great educational and networking opportunity - don't miss it!

  • Half-day agenda covering Toxicology and Oncology applications
  • Conveniently located on site of Bayern Innovativ Life Sciences Forum
  • Live demo of GravityPLUSTM cell culture platform
  • FREE event - no registration fees
  • Networking lunch included

Location:

Technische Universität München
Boltzmannstrasse 15
Building 5500; Room # 0234
85748 Garching, München
Germany

Time

Friday, March 13, 2015 from 08:30 to 13:30 CET

Preliminary Agenda:

We are actively working to build the best agenda possible for this event including speakers from InSphero and scientists using our technology, including academic, biotech and pharma researchers as well as our industry partners. The agenda above is tentative and subject to change.

08:30 - 09:05 Welcome reception and introduction

09:05 - 10:00 3D microtissue models for efficacy and safety testing - Jens M. Kelm, CSO and co-founder, InSphero AG, Switzerland

10:00 - 10:30 Imaging Bile Canaliculi in 3D InSightTM Human Liver Microtissues using the Opera PhenixTM High Content Screening System - Angelika Foitzik, Senior Applications Engineer, PerkinElmer Inc. 

10:30 - 11:00 Coffee break with demonstration

11:00 - 11:30 Application of in vitro assays to measure cellular response in 3D cell cultures - Axel Johann, Promega

11:30 - 12:00 Profiling metabolic and bioenergetics properties of 3D microtissues - Werner Kammerloher, Seahorse Bioscience

12:00 - 12:30 Development of an innovative 3D cell culture system to study tumour-stroma interactions in non-small cell lung cancer cells - Arno Amann, Medical University Innsbruck, Austria

12:30 - 13:30 Wrap-up & networking lunch

Register now!

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13.03.2015 - Promega Bioluminescent Cell-Based Assay Seminar Tour - Zurich

InSphero Hosts Promega Cell-Based Assay Seminar 

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Please join InSphero and Promega for presentations and discussions to learn more about the latest developments and applications in luminescent cell-based assays. We will be featuring presentations about the novel applications of NanoLuc® Luciferase for reporter assays and technologies for interrogating protein-protein interactions in living cells.

Network with your fellow scientists and get updated on the latest techniques for studying cell health and mechanisms of toxicity.

Presentations:

  • NanoLuc™: NextGen luciferase for analysis of protein dynamics and cell signaling
        Dr. Thomas Machleidt, Promega Corporation, USA
  • NanoBRET and NanoBiT: New Tools for the Analysis of Protein-Protein  Interactions in Living Cells
        Dr. Thomas Machleidt, Promega Corporation, USA
  • The Bright Side of 3D Biology
        Dr. Wolfgang Moritz, InSphero AG, Switzerland
  • GloMax® Discover! A multi-mode detection instrument for your assays
        Dr. Harald Winteler, Product Manager, Promega AG, Switzerland

Location:

Cytos Auditorium
Wagistrasse 25
Schlieren, Switzerland

Date and Time:

13 March, 2015 
9:30 - 14:30
Arrival, registration and coffee: 9:30 - 10:00

register now

View the entire 2015 Promega road show event schedule

22.03.-26.03.2015 - SOT 2015 - San Diego, CA, USA

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Discover 3D Toxicity Testing Made Simple

Meet InSphero at Booth #2318

SOT2015 Invite 260x180  Download your InSphero guide to SOT 2015

Meet the InSphero team in San Diego at the 54th Society of Toxicology Annual Meeting and ToxExpoTM.  With eight postersthree exhibitor hosted sessions, and our bigger and better ToxExpo booth and Beers and Spheres Social, this year's meeting offers plenty of opportunities to learn more about our industry-leading 3D microtissue models for more predictive toxicity and safety testing, including: 

  • See how industry leaders including Genentech, AstraZeneca, Biognosys, and PerkinElmer are finding 3D InSightTM Liver Microtissues to be a superior model for assessing long-term toxicity, ADC-mediated toxicity, DILI predictivity, compound-treated proteomic profiling, transporter efflux activity and more.
  • Explore toxicity beyond the liver with 3D pancreatic microislet, cardiac, and neuronal models
  • Learn how we're partnering with industry leading cell based assay, proteomics, and imaging companies to ensure you can make the most of our 3D model systems with optimized protocols
  • Discuss how our 3D experts can customize a contract research project to meet your needs
  • Join us for our Beers and Spheres social - Monday, March 23 at 7:00 PM

 

Liver Microtissues

Human liver spheroid

Source: Human, rat, HepG2 and more

Pancreatic Microislets

Islet no background

 Source: Human, rat

Literature References

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Browse our latest publications

 

Poster Presentations

Download Posters

Defeating the Animal: Alternative Systems for Neurotoxicity Testing
(presented by IfADo, Dortmund, Germany)
Abstract #248, Poster Board #414
Monday, March 23: 9:30 AM - 12:30 PM

Prodrug Activation in a Dynamic Microfluidics System Interconnecting Liver and Tumor Microtissues 
Abstract #449, Poster Board #136
Monday, March 23:  1:00 PM - 4:30 PM  

Standardized Rat and Human Microislets for Diabetes Research and Drug Safety Assessment
Abstract #1201, Poster Board #632
Tuesday, March 24: 9:00 AM - 12:30 PM

Evaluation of Spherical Liver Microtissues for In Vitro Cytotoxicity Assessment of Antibody-Drug Conjugates
(Presented by Genentech)
Abstract #892, Poster Board #115
Tuesday, March 24: 9:00 AM - 12:30 PM

Quantification of Efflux Transporter Activity in 3D Human Liver Microtissues
(Collaboration with PerkinElmer)
Abstract #2635, Poster Board #340
Thursday, March 26: 8:30 AM - 12:00 PM

Global Proteomic Profiling of Acetaminophen-Exposed 3D Human Liver Microtissues Identifies Novel NAPQI Adduct Sites
(Collaboration with Biognosys AG)
Abstract #2589, Poster Board #251
Thursday, March 26: 8:30 AM - 12:00 PM

Evaluation of the 3D InSightTM Human Liver Microtissues for the Detection of Compounds That Cause Drug-Induced Liver Injury in Humans
(Presented by AstraZeneca)
Abstract #2569, Poster Board #231
Thursday, March 26: 8:30 AM - 12:00 PM

Transmembrane Potential Measurements in Cardiac Microtissues Derived from Human Stem Cells
(Presented by University of Glasgow)
Abstract #2840, Poster Board #659
Thursday, March 26: 8:30 AM - 12:00 PM

Modifications Required for ATP and Caspase Detection Assays Applied to 3D Cell Spheroids
(Presented by Promega Corp.)
Abstract #2577, Poster Board #239
Thursday, March 26: 8:30 AM - 12:00 PM

 

Exhibitor Hosted Sessions

SLAS Tutorial

Join us for free continental breakfast!
3D microtissue cultures: use in long-term hepatocyte ADME-Tox studies

Co-presented with BioreclamationIVT
Monday, March 23
9:15 AM - 10:15 AM
Room 24B

InSphero and BioreclamationIVT present the latest data on the characterization of 3D human liver microtissues and their application to toxicity testing, drug metabolism studies and disease modelling. In addition, the attendees will learn about donor-to-donor differences and the use of liver non-parenchymal cells for 3D liver cultures.

 

3D microtissues meet OMICS technologies and high-content imaging
Monday, March 23
3:15 PM - 4:15 PM
Room 24C

OMICS technologies and high-content imaging have been demonstrated to be valuable tools to unravel biological pathways and phenotypic outcomes. This session aims to introduce the use of confocal imaging techniques, transcriptomics and proteomics in combination with organotypic 3D model systems to assess toxicological pathways and mechanisms.

 

3D liver models and beyond: 3D hepatic, cardiac, pancreatic, and neural microtissue models for toxicity testing
Tuesday, March 24
2:30 PM - 3:30 PM
Room 24C

3D liver microtissue models have demonstrated significant value as more organotypic systems for assessment of toxicity.  This session aims to cover the latest studies characterizing 3D InSight™ liver microtissues, and introduce novel 3D models for assessment of toxicity in non-liver organs, focusing on the heart, pancreas, and brain.   

Join us for cocktails at our 'Beers and Spheres' Event

Co-hosted by Promega and Cellular Dynamics International

Monday, March 23 7:00 PM - 10:00 PM
Don Chido - San Diego Gaslamp
527 5th Avenue
San Diego, CA 92101
Click for map

 

Register at the official meeting site.

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11.06.2015 - InSphero User Group Meeting, United Kingdom

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InSphero's Annual UK User Group Meeting

Join us Thursday, June 11 for a day of informative 3D cell culture presentations at InSphero's annual UK User Group Meeting, being held at the Trinity Centre, Cambridge, UK. We have prepared an exciting half-day agenda that brings together international experts in toxicology and efficacy testing using 3D in vitro systems. Secure your seat at this great educational and networking opportunity – you won't want to miss it!

  • Half-day agenda covering Toxicology and Oncology applications
  • Networking lunch included
  • Guest-speakers from AstraZeneca, University of Glasgow, Promega, Biognosys, and Seahorse Bioscience

Location:

Trinity Centre, Cambridge Science Park, UK

Date and Time:

Thursday, June 11, 2015
10:00 AM - 03:30 PM

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       Please put me on the waiting list!*
          


* the waiting list will be considered if a registered participant will cancel his participation prior to the User Group Meeting. Slots will be filled according to the date of the e-mail sent to us with a request to be placed on the waitinglist. For questions, please contact This email address is being protected from spambots. You need JavaScript enabled to view it.

 Current Agenda:

10:00 - 10:30       Welcome Reception and Introduction by Tony Rutt of InSphero

10:30 – 11:00      3D InSightTM Services Overview by Dr. Johannes Haugstetter of InSphero

11:00 – 11:30      Compound Classification Strategies Using Homo- and Heterotypic Tumor Microtissues
                               by Zoe Weydert, 
Master of Science at Zurich University of Applied Sciences (ZHAW)

11:30 – 12:00      Applications of in vitro assays to measure cellular response in 3D cell cultures by Dr. Marta Rucka of Promega

12:00 – 13:00      Networking Lunch incl. Live Demonstration

13:00 – 13:30      Understanding Cellular Metabolism of Spheroids Using Extracellular Flux Technology 
                               by Dr. Alex Liversage of Seahorse Bioscience


13:30 – 14:00      Use of Liver Microtissues for Drug Safety Assessment: an AstraZeneca Perspective 
                               by Alison Foster of Astra Zeneca

14:00 - 14:15       Short Break

14:15 – 14:45      Optical measurements of electrical activity and contraction from cardiac microtissues of iPS-derived cardiomyocytes
                               by Dr. Maria Hortigon, University of Glasgow and Clyde Biosciences Ltd., UK
   


14:45 – 15:15      Proteomic Profiling of 3D Human Liver Microtissues by Dr. Claudia Escher of Biognosys

15:15 – 16:00      Wrap up & Networking Coffee by Tony Rutt of InSphero

Click here to register for the 2015 InSphero UK User Group Meeting

20.11.2014 - InSphero User Group Meeting - Boston, MA, USA

Thursday, November 20th, 2014

Join us for our 3D Cell Culture Workshops!

Registration deadline: Monday, November 17th

insphero ugm uk

Whether you already use InSphero products or are thinking about upgrading your cell culture to 3D, our 2014 Boston User Group Meeting offers focused half-day workshops to get you up to date with the latest in 3D cell culture technology and applications. 

  • Half-day topical agendas for Toxicology (AM) and Oncology (PM)
  • Register for one or both sessions based on your interests
  • Guest speakers from PromegaSeahorse Bioscience, PerkinElmer, and Protea Biosciences
  • Live demos of GravityPLUSTM cell culture platform
  • Hands-on Cell3iMager demonstration (PM)
  • FREE event - no registration fees
  • Joint networking lunch included for both sessions

Location: 

Residence Inn Boston, Cambridge (view map)
6 Cambridge Center
Cambridge, MA  02142
617-349-0700

Time: 

Toxicology Session - 8:30 AM - 1:15 PM

Oncology Session - 12:30 PM - 5:00 PM

Cost:

There is no cost to participate.  Registration is required. 

Agendas:

View the final event program and meeting details.  

Toxicology Workshop

8:30 AM - 9:00 AM  Welcome reception and lite breakfast

9:00 AM - 12:30 PM  Toxicology Session

  • Profiling metabolic and bioenergetic properties of 3D microtissues. Sierra Kent, Ph.D., Seahorse Bioscience
  • Toxicity studies on 3D primary liver microtissues. Ty Voss, Ph.D., PerkinElmer
  • Validating cell health assays applied to 3D culturesTerry Riss, Ph.D. Promega
  • Organotypic 3D liver microtissues for more predictive in vitro toxicology.  Jens M. Kelm, Ph.D., InSphero
  • Beyond 3D liver models: 3D pancreatic, cardiac, and neural models for in vitro toxicity testing.  Jens M. Kelm, Ph.D., InSphero

12:30 PM - 1:15 PM  Networking lunch

Oncology Workshop

12:30 PM - 1:15 PM  Networking lunch

1:15 PM - 5:00 PM  Oncology Session 

  • Mass spectrometry imaging for the characterization of 3D microtissues.  Erin H. Seeley, Ph.D., Protea Biosciences
  • 3D tumor microtissues and co-culture models for oncology and drug discovery.  Jens M. Kelm, Ph.D. InSphero
  • Fast and easy monitoring of spheroid growth and morphology using the Cell3iMager.  Randy Strube, Ph.D. InSphero
  • Hands-on demonstration: Cell3iMager and GravityPLUSTM - Establishment and label-free time-course assessment of tumor spheroid growth

Space is limited!  Reserve your seat now.

 

Going to the Functional Analysis & Screening Technologies (FAST) Congress?  Extend your stay and join us!

If you are already planning to be in Boston for the FAST Congress, stick around for our in-depth 3D cell culture workshops.  The Residence Inn Cambridge is conveniently located 15 minutes from Boston Logan International airport, and just 18 minutes from the Hyatt Boston Harbor.  Click here for more information about FAST, including how to receive discounted registration courtesy of InSphero. 

13.11.2014 - Cell3iMager Demo Day - Schlieren, CH

Join us for Cell3iMager Demo Days!

If you are interested in fast and easy label-free imaging of spheroids using the SCREEN Cell3iMager, but would like to learn more about this imager and its capabilities, join us for our monthly Demo Days. Each event offers you the opportunity to visit InSphero's global headquarters in Schlieren, Switzerland for live, hands-on imager demonstrations and training from our 3D cell culture experts.  There is no cost to attend the training, and lunch is provided!

Click here for more information and to register for this Demo Day event. 

17.11.-19.11.2014 - FAST Congress - Boston, MA, USA

Meet InSphero at the Functional Analysis & Screening Technologies
(FAST) Congress - Booth #13

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Meet the InSphero team in Boston at the 2nd Annual FAST Congress!  FAST brings together a community of biologists, screening managers, assay developers, engineers and pharmacologists to navigate emerging trends and new strategies for advancing drug discovery through refined in vitro cell models and modern phenotypic screening. 

  • Learn how our 3D InSightTM Liver Microtissues and Tumor-stromal co-culture models deliver more predictive, biologically relevant in vitro assessment of toxicity, efficacy and disease modeling. 
  • Explore toxicity beyond the liver with 3D pancreatic microislet, brain, cardiac, and skin microtissue models
  • Discover how the Cell3iMager enables fast, label-free phenotypic screening of 3D spheroids
  • See how our 3D experts can customize a contract research project to meet your needs

 

Podium Presentations - Tuesday, November 18

10:45 AM - Organotypic Culture Models for Toxicology Track:  Evaluation of spherical 3D liver microtissues for assessing cytotoxicity of small and large molecules.  Dr. William Proctor, Scientist, Investigative Toxicology, Safety Assessment, Genentech

Drug-induced liver injury is a major cause of clinical attrition.  Spherical liver microtissues provide a stable 3D co-culture model to assess cytotoxicity over treatment durations not achievable with conventional hepatocyte cultures. Accordingly, this model is a promising tool for evaluating hepatotoxicity risk for both small and molecules and antibody-drug conjugates.

3:10 PM - Technology Showcase:  3D InSightTM Microtissues for Drug Discovery and Development.  Dr. Jens M. Kelm, InSphero AG

Increasing the biological significance of in vitro models to better de-risk drug failure will foster the drug discovery and developmental process. Microtissue models tailored either for efficacy testing or safety testing have shown to be a versatile culture format to be used throughout the whole development process.

View the online meeting program

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Save up to $200 on FAST registration!  

As a 2014 FAST Congress Sponsor, we have secured a discounted registration fee for you to attend the FAST meeting.  Register today and take $200 off the commercial rate, and $100 off the academic, government and hospital-affiliated rate by mentioning keycode 1419INS.  Call 781-972-5400 for more information. 

Register now at the official conference website.

Extend your stay in Boston - Join our User Group Meeting!

Thursday, November 20th

insphero ugm uk

Get updated on the latest 3D cell culture technology and applications for toxicology and oncology at our 1/2 day workshops on Thursday, November 20th. Conveniently located near the Boston Logan International airport!  Get meeting details.  

 

 

10.11.-11.11.2014 - IVTS Annual Meeting 2014, Macclesfield, UK

Visit InSphero at IVTS 2014

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and toxicology testing.

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Register now at the official conference website.

02.11.-05.11.2014 - EACR Conference Series 2014, Goodbye Flat Biology: 3D Models and the Tumour Microenvironment, Berlin, Germany

Visit InSphero at EACR’s Goodbye Flat Biology Meeting

Meet the InSphero team to learn how our scaffold-free organotypic 3D tumor microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for the evaluation of novel cancer therapeutics.

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Register now at the official conference website.

24.10.2014 - InSphero User Group Meeting - San Francisco, CA, USA

Friday, October 24th 2014

Join us for our 3D Cell Culture Workshops!
Registration for this event is now closed.

insphero ugm uk

Whether you already use InSphero products or are thinking about upgrading your cell culture to 3D, our 2014 San Francisco User Group Meeting offers focused half-day workshops to get you up to date with the latest in 3D cell culture technology and applications. 

  • Half-day topical agendas for Toxicology (AM) and Oncology (PM)
  • Register for one or both sessions based on your interests
  • Guest speakers from Genentech, Promega, Protea Biosciences, and PerkinElmer
  • Hands-on Cell3iMager and GravityPLUSTM cell culture platform demonstration (PM)
  • FREE event - no registration fees
  • Joint networking lunch included for both sessions

Location: 

DoubleTree San Francisco Airport North (View on map)
5000 Sierra Point Pkwy
Brisbane, CA 94005
Phone: (415) 467-4400

Time: 

Toxicology Session - 8:30 AM - 1:15 PM

Oncology Session - 12:15 PM - 5:00 PM

Cost:

There is no cost to participate.  Registration is required.

Agendas:

View the event program and meeting details.

Toxicology Workshop

8:30 AM - 9:00 AM  Welcome and lite breakfast

9:00 AM - 12:15 PM  Toxicology Session

  • Evaluation of InSphero 3D Liver Microtissues for Assessing Cytotoxicity of Small Molecule Drugs and Antibody Drug-Conjugates.  William Proctor, Ph.D. - Investigative Toxicology, Safety Assessment, Genentech
  • Validating cell health assays applied to 3D cultures. Sandra Nguyen, Field Application Specialist, Promega
  • Toxicity studies on 3D Primary Liver Microtissues. Kevin Quick, Ph.D., Americas Technical Applications Director, PerkinElmer
  • 3D liver models and beyond: organotypic 3D microtissues for more predictive in vitro toxicity testing.  Patrina Gunness, Ph.D., InSphero

12:15 PM - 1:15 PM  Networking lunch

Oncology Workshop

12:15 PM - 1:15 PM  Networking lunch

1:15 PM - 5:00 PM  Oncology Session

  • Mass spectrometry imaging for the characterization of 3D microtissues
    Erin H. Seeley, Ph.D., Senior Scientist, MALDI Mass Spec Imaging, Protea Biosciences
  • 3D tumor microtissues and co-culture models for efficacy and target discovery.
    Randy Strube, Ph.D., InSphero
  • Fast and easy monitoring of spheroid growth and morphology with the Cell3iMager. Randy Strube, Ph.D., InSphero
  • Hands-on demo: Spheroid production and imaging with the GravityPLUSTM Platform and Cell3iMager

 

Going to the ISSX/JSSX Joint Meeting?  Extend your stay and join us!

If you are already in town for the ISSX/JSSX meeting, stick around for an in-depth 3D cell culture workshop.  The DoubleTree hotel is conveniently located just 10 minutes from the SFO airport, and offers complimentary airport shuttle service.

  

19.10.-23.10.2014 - ISSX/JSSX 2014 Joint Meeting - San Francisco, CA, USA

Meet InSphero at ISSX/JSSX - Booth #514

Meet the InSphero team in San Francisco at the 2014 joint meeting of the North American and Japanese regions of the International Society for the Study of Xenobiotics (ISSX/JSSX).  

  • Learn how our 3D InSightTM Liver Microtissues deliver metabolic competency for more predictive, biologically relevant in vitro assessment of toxicity/DMPK, efficacy and disesase modeling
  • Explore toxicity beyond the liver with 3D pseudoislet, brain, cardiac, and skin microtissue models
  • See how our 3D-focused Toxicology Services can speed up your safety testing workflow
  • Discover the 3D InSightTM Cytotoxicity Assay Kit for monitoring viability in 3D microtissues using Promega technology 

Poster Presentation - Tuesday, October 21 - 12:30-1:15 PM

#P273 - 3D organotypic human HepaRG spheroid cultures for in vitro toxicological studies

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Register now at the official conference website.

Extend your stay in San Francisco - Join our User Group Meeting!

Friday, October 24th

insphero ugm uk

Get updated on the latest 3D cell culture applications for toxicology and oncology at our 1/2 day workshops on Friday, October 24th. Conveniently located near the SFO airport!  Get meeting details

  

 

 

 

 

 

 

 

 

 

15.10.2014 - Cell3iMager Demo Day - Schlieren, CH

Join us for Cell3iMager Demo Days!

If you are interested in fast and easy label-free imaging of spheroids using the SCREEN Cell3iMager, but would like to learn more about this imager and its capabilities, join us for our monthly Demo Days. Each event offers you the opportunity to visit InSphero's global headquarters in Schlieren, Switzerland for live, hands-on imager demonstrations and training from our 3D cell culture experts.  There is no cost to attend the training, and lunch is provided!

Click here for more information and to register for this Demo Day event. 

15.10.-17.10.2014 - BioJapan 2014 World Business Forum, Yokohama, Japan

Meet InSphero at BioJapan 2014 - Booth #C513

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InSphero is partnering with SCREEN Holdings Co., Ltd., manufacturer of the Cell3iMager, and our Japanese distributor BizCom Japan, Inc. at the BioJapan 2014 World Business Forum.  Meet our team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and efficacy testing.

SCREEN Holdings Sponsored Luncheon:

Friday, October 17 - 12:00 - 13:00 (Annex Hall F205/F206)

Automated Analysis of Scaffold-free 3D Tumor Microtissues: From Discovery to Target Validation
Wolfgang Moritz, Ph.D., InSphero AG

HTS friendly Anticancer Drug Screening in 3D Culture by Dainippon SCREEN Cell3iMager: Different Sensitivity of Single Spheroid Cancer Cells with Activation of NRSF, Myc, or K-Ras.
Hirofumi Nakano, Tokyo Institute of Technology

Featured Exhibitor Presentation:

Friday, October 17 - 14:50-15:05 (Room B)

3D Microtissues: A Versatile Tool for Drug Development and Safety Assessment
Wolfgang Moritz, Ph.D. - Co-founder and Head of Research and Applications, InSphero AG

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Register now at the official conference website.

bizcomjapan-insphero-distributor

Dainippon Screen logo

09.10.-10.10.2014 - Congrès annuel de la SPTC, "Horizon 2020, Le défi cellulaire en toxicologie", Rennes et La Gacilly, France

Visit InSphero at SPTC Annual Meeting 2014

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and toxicology testing.

  • Stop by at our booth in the exhibition area or
  • join our scientific presentation "Cultures 3D en toxicologie : hépatocytes et autres cellules" on day 2, 10:30 AM - 11:00 AM

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Register now at the official conference website.

09.10.2014 - Competence Centre TEDD Annual Meeting 2014, Waedenswil, Switzerland

Tissue Engineering for Drug Development and Substance Testing (TEDD) Annual Meeting

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and efficacy testing.

Program and registration information at official meeting website.

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Click to register now!

06.10.2014 - 2014 CDI European User Group Meeting, London, UK

Learn about our iPS-Derived 3D Brain Model at CDI Meeting

InSphero will present progress on an iPS-derived 3D brain model at the Cellular Dynamics 2014 European User Group Meeting being held in London, UK on October 6th.  The workshop, entitled "Advances in Human iPSC-derived Cell Models for Phenotypic Screening & Toxicity Studies" is a free multi-session conference with speakers from industry and academia using CDI's iCell(R) technology in their research.

View the full agenda, and register to attend here.

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26.09.2014 - SLAS Short Courses, 3D Cell-based Assays for Drug De-risking, Basel, Switzerland

Meet InSphero at SLAS Short Courses in Basel

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and efficacy testing.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Register now at the official conference website.

24.09.-26.09.2014 - BIOSPAIN 2014, Santiago de Compostela, Spain

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and efficacy testing.

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Register now at the official conference website.

23.09.-25.09.2014 - MipTec 2014, Basel, Switzerland

Meet InSphero at MipTec - Promega booth #D25

Meet the InSphero team at MipTec 2014 to learn how our new 3D InSight™ Cytotoxicity Assay Kit reliably monitors the viability of 3D microtissues based on Promega technology. Stop by at Promega booth #D25, our experts are waiting for you!

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Register now at the official conference website.

18.09.2014 - Cell3iMager Demo Day - Schlieren, CH

Join us for Cell3iMager Demo Days!

If you are interested in fast and easy label-free imaging of spheroids using the SCREEN Cell3iMager, but would like to learn more about this imager and its capabilities, join us for our monthly Demo Days. Each event offers you the opportunity to visit InSphero's global headquarters in Schlieren, Switzerland for live, hands-on imager demonstrations and training from our 3D cell culture experts.  There is no cost to attend the training, and lunch is provided!

Agenda:

11:00 General introduction to InSphero and the Cell3iMager
12:00 Lunch
12:30 Hands on training in our lab

  • Instrument setup
  • Scanning microtissues
  • Measuring microtissues
  • Data analysis and export

15:30 Session ends

 

When:

  • Thursday, 18 September
  • Wednesday, 15 October
  • Thursday, 13 November

Registration:

Click here to register for a Demo Day event, or This email address is being protected from spambots. You need JavaScript enabled to view it. for more information.

Where: 

All Demo Days events will be held at the InSphero AG Headquarters in Schlieren, Switzerland located just outside Zurich.

InSphero AG
Wagistrasse 27
8952 Schlieren
Switzerland

Cost: 

There is no cost to register for the event, however all attendees are responsible for their own travel and housing arrangements. 

Travel and Accommodations:

Please contact us if you need assistance with local travel or recommended hotels in the vicinity.  

17.09.2014 - InSphero-Toolpoint Scientific Forum, Schlieren, Switzerland

Challenges and opportunities in the development of novel anti-tumor therapies
Potential contribution of cell models

Join us for an exciting forum discussion with leading experts in the field - don’t miss this great educational and networking opportunity!

Program and registration information here.

Click to register now!

12.09.2014 - 3D Cell-Culture Workshop, Singapore

Predictive Drug De-risking with 3D Cell-based Assays

An afternoon full of exciting talks is waiting for you at this workshop co-hosted with our partners Acumen Research Laboratories and PerkinElmer- don't miss it!

Program and free registration information here.

07.09.-10.09.2014 - EUROTOX 2014 - 50th Congress of the European Societies of Toxicology, Edinburgh, UK

Visit InSphero at EUROTOX 2014 - Booth 41

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and toxicology testing.

  • Learn about the advantages of our assay-ready 3D liver microtissues and novel spheroid models developed for assessment of toxicity in non-liver organs

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Register now at the official conference website.

Visit InSphero Poster Presentations

  • Characterization of heterotypic 3D human liver microtissues for drug-induced hepatotoxicity testing
    • Poster number P-2.159, Poster session 2, Monday 8 September
    • Co-presented with Karolinska Institutet Sweden
  • Organotypic human HepaRG spheroid cultures for in vitro toxicity studies
    • Co-presented with Biopredic International Ltd. France
  • Human neural microtissues derived from induced pluripotent stem cells for toxicity testing
    • Poster number P-2.160, Poster session 2, Monday 8 September
    • Co-presented with Leibniz Research Centre for Working Environment and Human Factors Germany & Cellular Dynamics USA
  • Global proteomic analysis of acetaminophen toxicity in 3D human liver microtissues
    • Poster number P-4.96, Poster session 4, Tuesday 9 September
    • Co-presented with Biognosys AG Switzerland

02.09.-03.09.2014 - ELRIG Drug Discovery '14, Manchester, UK

Visit InSphero at ELRIG DD'14 - Booth C8

Meet the InSphero team to learn how our scaffold-free, organotypic 3D microtissues, and 3D optimized assays, enable more relevant in vitro applications for drug discovery and development.

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Register now at the official conference website, participation is free.

Booth highlight SCREEN Cell3iMager

Stop by and discover how the new Dainippon SCREEN Cell3iMager, together with our automation-friendly GravityPLUS™ platform can simplify your 3D cell culture workflow. The imager provides rapid and robust profiling of spheroid growth and morphology, and is fully compatible with our GravityTRAP™ assay plates.

Attend our SLAS Short Course on Sep 1

New! 3 one-day SLAS Short Courses will be held alongside this year’s Drug Discovery event, one of which is co-presented by InSphero.

  • COURSE 3: Establishing Cell-Based Assays and Implementing 3D Culture Models for screening and drug testing
    • Date: Monday, September 1
    • Abstract: This course will describe developing standard procedures for handling cultured cells to set up cell-based assays, describe techniques for measuring cell health and the mechanisms leading to cytotoxicity, and provide an overview of recent technological advances in 3D culture technologies that enable automation-compatible drug testing with more predictive and biologically relevant assays. Case studies will be presented which provide examples of using 3D model systems for screening and drug testing.
    • Co-presented with Promega Corporation
    • More information and registration on official conference website

24.08.-28.08.2014 - 9th World Congress on Alternatives and Animal Use in the Life Sciences, Prague, Czech Republic

Visit InSphero at WC9 - Booth No. 30

Meet the InSphero team to learn how our scaffold-free, organotypic 3D microtissues, and 3D optimized assays, enable 3R-relevant in vitro applications for drug discovery and development.

View InSphero posters from the WC9.

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Visit the official conference website.

Visit InSphero Oral and Poster Presentations

Orals

  • Organotypic human HepaRG spheroid cultures for in vitro toxicity studies
    • I-4a-612, Monday, 25 August, 13:30 PM – 15:00 PM
    • part of session I-4a “3D Liver models”
    • Co-presented with Biopredic International Ltd. France 
  • Characterization of heterotypic 3D human liver microtissues for drug-induced hepatotoxicity testing
    • I-4a-785, Monday, 25 August, 13:30 PM – 15:00 PM
    • part of session I-4a “3D Liver models”
    • Co-presented with Karolinska Institutet Sweden
  • Developments towards physiologic in vitro models in Switzerland
    • I-3a-913, Tuesday, 26 August, 10:00 AM – 12:00 PM
    • part of session I-3a “Tissue on a chip / Human-on-a-chip”
    • Co-presented with Competence Centre for Tissue Engineering for Drug Development (TEDD) Switzerland
  • The throughput-compatible embryonic stem cell test (EST)
    • I-2-511, Wednesday, 27 August, 10:00 AM – 12:00 PM
    • part of session I-2 “High throughput screening (HTS) models”

 Posters

  • Human and rat neuronal microtissues for toxicity testing
    • I-4-335
    • part of session I-4 “Novel 3D models”
    • Co-presented with Cellular Dynamics International USA
  • Global proteomic analysis of acetaminophen toxicity in 3D human liver microtissues
    • I-4-397
    • part of session I-4 “Novel 3D models”
    • Co-presented with Biognosys AG Switzerland
  • Automation-compatible EST assay
    • I-2-582, Wednesday, 27 August
    • part of session I-2 “High throughput screening (HTS) models”
  • Microtissues meet microfluidic: A multi-parallel body on a chip concept
    • I-3-792, Tuesday, 26 August
    • part of session I-3a “Tissue on a chip / Human-on-a-chip”
    • Co-presented with ETH Zurich Switzerland and IFADo Germany

Posters will be presented during lunch break and after afternoon lectures. Check official program for updates.

15.07.2014 - NC3Rs/MHRA Meeting, Overcoming the barriers to wider uptake of human tissue for safety assessment, London, UK

Visit InSphero booth and poster presentation at NC3Rs/MHRA Meeting

Meet the InSphero team to learn how our scaffold-free, organotypic 3D human microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety testing.

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Attendance is free, register now at the official meeting website.

25.06.-27.06.2014 - Dechema 3D Cell Culture 2014 - Advanced Model Systems, Applications & Enabling Technologies, Freiburg, Germany

Visit InSphero at 3DCC 2014 – Booth B1

Meet the InSphero team to learn how our scaffold-free, organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for efficacy and toxicology testing.

In-booth highlights

Visit InSphero Lecture and Poster Presentations

Lectures

  • 3D microtissues for the discovery of chemoradiation-sensitizing compounds
    • Wednesday, 25 June, 17:15 PM – 17:35 PM
    • Co-presented with Helmholtz Zentrum München and Sirion Biotech GmbH
  • Studying gene function analysis in 3D tumor microtissue models
    • Thursday, 26 June, 9:45 AM – 9:55 AM
    • Co-presented with ETH Zurich
  •  Human 3D osteosarcoma models for drug testing
    • Thursday, 26 June, 10:05 AM – 10:15 AM
    • Co-presented with Zurich University of Applied Sciences and University Hospital Balgrist
  •  Characterization of single and co-cultured human iPSC-derived cardiomyocytes and cardiac fibroblasts in scaffold-free 3D microtissues
    • Thursday, 26 June, 14:45 PM – 15:05 PM
    • Co-presented with Bern University and Bern University Hospital

 Posters

  •  P1.18 - A novel vascular 3D microtissue model for HTS-compatible testing of vaso-constrictors and –dilators
    • Co-presented with King's College London
  • P1.19 - Standardized high-purity human pancreatic islets amenable to high throughput screening in diabetes research
    • Co-presented with University Hospital Zurich
  • P3.1 - Long-term in vitro 3D co-cultured human liver microtissues: characterization and implication for drug-induced hepatotoxicity studies
    • Co-presented with Karolinska Institutet
  • P4.2 - Improving cell based models through viral vector technology - chances for target research and personalized treatment strategies
    • Co-presented with Sirion Biotech GmbH, Helmholtz Zentrum München
  • P8.1 - Unbiased discovery of acetaminophen toxicity in 3D human liver microtissues by global proteomic analysis
    • Co-presented with Biognosys AG

 Attend Pre-Conference Liver Workshop on 24 June, co-organized by InSphero

This satellite event in advance of the 3D Cell Culture conference will provide deep insight in the prospects and challenges of advanced liver models for toxicological profiling. Find details and registration here.

 

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Register now at the official conference website.

18.06.2014 - International Society for Stem Cell Research (ISSCR), Vancouver, BC, Canada

Visit InSphero and Dainippon SCREEN at ISSCR Conference

InSphero will be teaming up with Dainippon SCREEN at the upcoming ISSCR meeting in beautiful Vancouver, BC.  Visit us at booth #424 to learn how InSphero's GravityPLUSTM 3D cell culture and assay platform enables faster, automation compatible production of embryoid bodies (EBs) in hanging drops, and how the new Dainippon SCREEN Cell3imager facilitates rapid anaylsis of EB size over long-term culture. 

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Register now at the official conference website.





10.06.-13.06.2014 - ESTIV2014 - 18th International Congress on in vitro Toxicology, Egmond aan Zee,The Netherlands

05.06.2014 - InSphero User Group Meeting, Zurich, Switzerland

Predictive drug de-risking with 3D-cell-culture systems

A full day of exciting talks is waiting for you at InSphero’s fourth annual user group meeting in Zurich - don't miss it!

Program and registration information here.

Click to register now!

04.06.2014 - ELRIGfr Conference „Screening with label-free technologies“, Lausanne, Switzerland

Visit InSphero booth at ELRIGfr Conference

Meet the InSphero team to learn about the new Dainippon SCREEN Cell3imager, allowing rapid imaging of 3D tumour spheroids and ideally useable in combination with InSphero's GravityPLUS™ 3D microtissue culture platform.

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Register now at the official conference website.

18.05.-22.05.2014 - MDO 2014 - 20th International Symposium on Microsomes and Drug Oxidations, Stuttgart, Germany

Visit InSphero at MDO 2014 – Booth #15

Meet the Scy-Dis International team, our official German distributor, to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for drug discovery and development.

To arrange an on-site meeting contact This email address is being protected from spambots. You need JavaScript enabled to view it..

Register now at the official conference website.

16.05.2014 - InSphero - Scy-Dis User Group Meeting, Heidelberg, Germany

Zuverlässige Substanztestung in 3D-Zellkultursystemen

Predictive Drug De-risking with 3D Cell-based Assays

InSphero's second user group meeting in Germany, co-hosted with our distributor Scy-Dis International, will bring together experts in efficacy and toxicology testing with 3D in vitro systems. This free, half-day event is a great educational and networking opportunity - don't miss it!

Program and registration information here.

Click to register now!

05.04.-09.04.2014 - AACR Annual Meeting 2014, San Diego, CA, USA

Upgrade your cancer research to 3D!

Visit InSphero at AACR booth #409 to learn more about our industry-leading portfolio of products and services for 3D tumor biology, efficacy and drug discovery.

Highlights include GravityPLUS™/GravityTRAP™ hanging drop plates, 3D InSight™ Fluorescent Tumor Microtissues, tailored 3D InSight™ Oncology Services, and the new Cell3iMager from Dainippon SCREEN.

Attend Poster Presentations

  • Abstract #2029: Insight of 3D multicellular tumor spheroids for innovative culture models of potential relevance for the screening of anti-CRC compounds
    • Monday, April 7 - 1:00 PM - 5:00 PM
    • Presented by University of Basel, Switzerland
  • Abstract #2017: Development of a novel 3D tri-culture system in an in vitro non-small cell lung cancer (NSCLC) model
    • Monday, April 7 - 1:00 PM - 5:00 PM
    • Presented by Medical University Innsbruck, Austria
  • Abstract #3731: Luminescent cell health assays for tumor spheroid evaluation
    • Tuesday, April 8 - 8:00 AM - 12:00 PM
    • Co-presented with Promega Corp., USA

In-booth highlights

  • Make hanging drops...see how easy it is to make, transfer, and assay tumor spheroids
  • View tumor microtissues under the scope
  • Get an InSphero drawstring backpack

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Register now at the official conference website.

23.03.-27.03.2014 - SOT 2014 53rd Annual Meeting and ToxExpo, Phoenix, AZ, USA

Visit InSphero at SOT 2014 (ToxExpo Booth #972)

Meet the InSphero team to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for safety and toxicology testing.

  • View our 3D liver microtissues under the scope
  • Learn about the advantages of assay-ready 3D liver microtissues
  • Take the InSphero challenge and you could win an iPad mini!

Attend our two Exhibitor Hosted Sessions

  • EHS #56: Advanced 3D liver co-culture models for predictive in vitro testing
    • Date: Monday, March 24
    • Time: 3:30-4:30 PM
    • Room # 106A West
    • Abstract: Co-cultures of important hepatic cell types, including Kupffer cells, in scaffold-free 3D microtissues offer novel perspectives to predictive in vitro testing. Case studies show the benefits of 3D models for applications in long-term, idiosyncratic toxicity and DMPK/ADME testing. Advanced endpoints, including proteomics and transcriptomics will be introduced during this session.
  • EHS#62: Beyond 3D Liver Models: Cardiac, pancreatic, and neural 3D microtissue models for toxicity testing
    • Date: Wednesday, March 26
    • Time: 11:45 AM-12:45 PM
    • Room # 106A West
    • Abstract: 3D liver microtissue models have demonstrated significant value as more organotypic systems for assessment of toxicity. This session aims to go beyond our discussion of liver models (EHS #56) to introduce development of 3D microtissues for assessment of toxicity in non-liver organs, focusing on the heart, pancreas, and brain.

Visit InSphero Poster Presentations

  • Abstract #1047 – Long-Term In Vitro Three-Dimensional Co-cultured Human Liver Microtissues: Characterization and Implication for Drug-Induced Hepatotoxicity Studies
    • Tuesday, March 25 – 9 AM-12 PM
  • Abstract #1890 – Global Proteomic Analysis of Acetaminophen Toxicity in 3D Human Liver Microtissues
    • Wednesday, March 26 – 1 PM - 4:30 PM
    • Co-presented with Biognosys AG
  • Abstract #291 – Verifying Performance of Cell Viability and Apoptosis Assays Applied to 3D Microtissues
    • Monday, March 24 – 9:30 AM – 12:30 PM
    • Presented by Promega
To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Register Now at the Official Conference Website.

InReview

InSphero at SOT 2014Thank you to the more than 250 SOT attendees that visited the InSphero booth and our scientific presentations in Phoenix last week! If you participated in the InSphero Challenge, we will select the winner of our iPad Mini drawing in the coming days and announce the winner to those who entered. If you had specific requests to receive literature or presentations from our exhibitor hosted sessions, an InSphero representative will be in contact with you shortly. We look forward to seeing you in San Diego at SOT 2015!

 

12.03.2014 - InSphero-Cambridge Bioscience User Group Meeting, Cambridge, UK

3D cell-based assays in predictive toxicological studies

InSphero’s third user group meeting in the UK, co-hosted with our distributor Cambridge Bioscience, will bring together experts in safety and toxicology testing with 3D in vitro systems. This free, half-day event is a great educational and networking opportunity - don't miss it!

Program and registration information here.

Click to register now!

InReview: Cambridge Bioscience packs house for UK user group meeting

Over 60 people attended InSphero's recent user group meeting in Cambridge (UK) to hear talks on InSphero's microtissue technology and ready-to-use, long-lifetime microtissue models. Long-lifetime 3D InSight™ Liver Microtissues were shown to be suitable for bile acid analysis using LC/MS (Pharmacelsus) and for generating high content protein expression data using a next-generation proteomics platform (Biognosys).This email address is being protected from spambots. You need JavaScript enabled to view it. if you are interested in receiving more information about these presentations, or would like to present your data at one of our upcoming user group meetings.

 

11.03.2014 - ELRIG Research and Innovation 2014: Technology’s Impact Into Cancer Research and Therapeutics, Telford, UK

Meet the InSphero team at the ELRIG conference to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Register now at the official conference website.

27.02.-28.02.2014 - IT-LIVER Workshop: 3-Dimensional Cell Cultures and Drug Discovery, Vienna, Austria

Meet the InSphero team and join our presentation at the Workshop organized by the Marie Curie ITN Project „IT-LIVER" to learn how our scaffold-free, multi-cell type 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for drug discovery.

  • InSphero presentation "Discriminating drug effects in multi-cell type 3D microtissues", part of session 5: "Preclinical Drug Application in 3D", Friday, February 28 from 11:00 AM to 12:05 PM, check final program for updates
To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Register now at the official workshop website.

24.02.-26.02.2014 - IVAL Inaugural Boston Hepatocyte Conference, Malden, MA, USA

Meet the InSphero team at the IVAL - In Vitro ADMET Laboratories' Conference to learn how our scaffold-free organotypic 3D liver microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for ADMET.

  • Booth in exhibition area
  • Presentation "3-dimensional Liver Models for Toxicological Assessment", Monday, February 24 from 5:45 PM to 6:15 PM, check final program for updates
  • Hands-on Training "3D Liver Microtissue (LiMT): Receiving, Dosing and Toxicological Assessment", part of "Hepatocyte Laboratory Workshop: Hands on Training on the Application of Cryopreserved Human Hepatocytes in Drug Development; Hands-on Training in Hepatocyte Technologies", Tuesday and Wednesday, February 25-26, check final program for updates
To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Register Now at the Official Conference Website.

18.01.-22.01.2014 - SLAS 2014 3rd Annual Conference & Exhibition, San Diego, CA, USA

Meet the InSphero team, visit our booth or presentations at SLAS 2014 to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for efficacy and safety testing.

  • Booth number 1411
  • Short Course “3D Cell-based Assays for Drug De-risking”, Sunday, January 19 from 8:30 AM to 4:30 PM, check official program for details
  • Podium Presentation "Studying Gene Function in 3D Microtissue Models", part of session "Automation & High-Throughput Technologies; Illumination of the Druggable Genome Through High-Throughput Technologies", Tuesday, January 21 from 4:00 PM to 4:30 PM, check final program for updates
  • Podium Presentation by PerkinElmer "High Content Analysis and 3D Microtissues – Friend or Foe?", part of session "Assay Development and Screening; High Content Screening", Tuesday, January 21 from 3:30 PM to 4:00 PM, check final program for updates
To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

16.01.-17.01.2014 - FutureTox II: In Vitro Data and In Silico Models for Predictive Toxicology, Chapel Hill, NC, USA

Meet the InSphero team at FutureTox II meeting to learn how our scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable biologically more relevant in vitro applications for toxicity and safety testing.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official meeting website.

13.10.2016 - New Frontiers in 3D Cell Culture-based Screening Technologies

nf conference

Full-day event on 3D microtissue models for more relevant translational screening methods and safety testing.

Advanced 3D tissue models are changing the shape of in vitro testing for drug discovery and development from flat, monolayer cell culture to more complex 3D systems providing greater physiological relevance. The inaugural New Frontiers Conference aims to establish an international forum in which to discuss integration of advanced 3D models throughout the drug discovery and development process, with an emphasis on translational approaches, challenges, and successes. This one-day symposium will include sessions on current state-of-the-art 3D model systems for drug discovery and toxicology/safety testing, including keynote and invited speakers representing industry, regulatory, and academic perspectives on each topic. Join the discussion in the inaugural 2016 meeting, and help shape the direction of advanced in vitro models. Poster abstracts submitted by September 2, 2016 will be considered for one of six attendee podium presentations.

Date:
October 13, 2016

Time:
7:30 AM - 6:00 PM

Venue:
Johns Hopkins University - Charles Commons
10 E. 33RD STREET, BALTIMORE, Maryland 21218, USA

Conference Program

Register here

more Infos

19. - 20.11.2015 - FutureTox III: Bridges for Translation

 FutureTox3 

Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making
 

The 21st Century vision and strategy for assessing toxicity (TT21C science or Tox21 hereafter) was developed with the intent to increase throughput, decrease cost, and optimize chemical data collection for increased utility and relevance to inform chemical safety decision-making. Central to this strategy is the ability to predict human health risks from emerging ‘‘big data” and novel in vitro data collections using in silico models for exposure and hazard assessment. Automated high-throughput screening (HTS) and high-content screening (HCS) of large chemical inventories, together with newer complex culture models utilizing human cells, microtissue systems, and integrative models, are now providing vast amounts of data that can be used to inform regulatory toxicity testing. These methods, together with novel approaches to model exposure and kinetics, creates an opportunity for a paradigm shift toward diversified and high-throughput risk assessment (HTRA) approaches for regulatory decision-making. Overall, the approach results in more rapid, more relevant, and more nimble discovery-screening and prioritization efforts with less reliance on animal testing. The time is right to discuss and debate how TT21C science, approaches, and technologies will be applied in risk assessment and regulatory decision-making.

Date:
19. - 20. November, 2015

Venue:
Hilton Crystal City at Washington National Airport, Arlington, Virginia

Posters:
Characterization of 3D HepaRG microtissues for long-term toxicity studies

Pro-drug activation and detoxification in a dynamic
microfluidic system

OMICS analysis of human liver microtissues stability grown over 4 weeks

 

More information about the FutureTox III

 

02.12.2015 - Promega, InSphero & BD Bioscience Seminar: Reliable Methods & Tools to Study Cellular Responses

promega seminar

Promega, InSphero & BD Bioscience Seminar: Reliable Methods & Tools to Study Cellular Responses

Promega, InSphero & BD Biosciences will give scientists the opportunity to learn about various methods and tools to study different aspects of cellular biology.

Location: ARCHOTEL Wimberger, Neubaugürtel 34-36, 1070 Vienna, Austria

Date and Time: Wednesday, 02 December 2015, 10:30 - 15:00

Speakers:

Dr. Sumeer Dhar of InSphero: Increasing biological relevance in vitro: From single microtissues to micro-physiological systems.

Dr. Jan Adam of Promega, Cell-Based Assays to study cellular health and responses.

Dr. Angela Engel of BD Biosciences: Flow Cytometry: Analyse cellular status and responses on single cell level and sort individual cells for molecular biology assays.

Register here!

View Flyer here!

InSphero AG


Logo

Increasing biological relevance in vitro: From single microtissues to micro-physiological systems.

Cell-based assays have become an inherent part in drug discovery and development to predict the in vivo response to biologicals and chemicals. Cells are used throughout the whole developmental chain as a test system: (i) drug target validation, (ii) primary and secondary screening set up’s, (iii) lead optimization and (iv) toxicological profiling. Current standard technology is based on the culture of mammalian cells, either primary or cell lines, as monolayers in plastic dishes. However, to gain the maximum benefit of in vitro cell cultures for drug de-risking, cells have to be maintained in a format which reflects in vivo cellular functionality, either animal or human, as closely as possible. To further increase in the value of in vitro models, technologies which allow direct cell-cell and inter-tissue communication are essential. Therefore, advanced 3D cell culture models are gaining momentum as the development of new therapeutics is a time and cost intensive process profiting from better drug de-risking. With this objective, scalable and automation-compatible tissue engineering strategies are being exploited to further improve the predictive power of cell-based assays. Here microtissue technology is being presented which allows on the one hand high throughput efficacy and safety testing and on the other flexible design of microphysiological systems. 

Promega

promega

Cell-Based Assays to study cellular health and responses.

The assessment of cell health and cellular responses after experimental manipulation continue to be a very important aspect of experimental biology. In this context cell-based assays are highly valuable tools to study different cellular responses in an “add-mix-measure” format. The seminar provides an overview of the most sensitive and easy-to-use cell-based assay formats to study cell-viability, cytotoxicity and cellular pathway activation with focus on the fascinating luciferase technology. Furthermore, practical tips and tricks to avoid pitfalls will be discussed in more detail.  

BD Biosciences

BD Biosciences

Flow Cytometry: Analyse cellular status and responses on single cell level and sort individual cells for molecular biology assays.

The balance of various processes in the lifecycle of a cell is important for both development and normal tissue homeostasis. Depending on the initial trigger or the time point of the analysis cells show a slightly different pattern of marker expression or protein phosphorylation in cell signaling pathways. The result of each experiment gets as more significant as more parameters can be analyzed simultaneously. This presentation illustrates tools and techniques to explore various indicators for cellular responses on a single cell basis. The way to make flow cytometry analysis and sorting easy-to-use and practical tips on the assays will be covered.  

 

 

 

03.12.2015 - Information Day on „Good Cell Culture Practice: Human Stem Cells and Organoids“

 Information day 

The advances in cell culture techniques and the establishment of in vitro test systems in research need to be accompanied with approaches to standardize processes and documentation. The "Bologna Statement on Good Cell Culture Practice" in 1999 prompted the ECVAM Task Force on Good Cell Culture Practice (GCCP) to produce two seminal guidance documents (1-2). Additional refinements were introduced in 2011 (3). With growing availability of cultured organoids, and the increasing generation and use of pluripotent stem cells and their differentiation progeny, there is a need for revision and update of the GCCP guidelines for these new technologies. This includes quality assurance of supplied biological materials as well as consideration of ethical and legal aspects. This symposium has the focus on GCCP regarding human cells and tissues and the quality assurance of cells obtained by reprogramming.

Date:
03. December 2015, 09:00 - 16:00

Venue:
Konzil Konstanz (Council Building), Konstanz, Germany

More information about the Information Day

23. - 27.01.2016 - SLAS 2016

  SLAS 2016

Get 3D InSight™ at SLAS2016

The annual conference of the Society of Laboratory Automation and Screening is where science research and development professionals gather to learn about the lastest and greatest laboratory tools and technologies available and how they are being applied by their peers. If you're interested in 3D microtissue technology for drug discovery and development or disease modeling, InSphero will be hosting several educational events you won't want to miss.

Screen with greater relevance in 3D

Are you screening in 3D? InSphero can help you begin or advance your screening in organotypic 3D models with solutions to ASSAY, IMAGE, and AUTOMATE in 3D. Visit one of our presentations or find us at Booth #307 to gain 3D InSight™ from our experts in microtissue technology:

ASSAY

Assay-ready 3D InSight™ Microtissues – standardized 3D models and optimized medium delivered conveniently to your lab, ready to screen
3D InSight™ Services – let our experts test your compounds in our proprietary 3D models with standard and custom service offerings
Technical Protocols - refer to our 3D optimized assay protocols to learn how to make the most of your investment in microtissues

IMAGE

SCREEN Cell3iMager Neo – the best tool for scanning and measuring spheroid size and morphology
Application Notes – the latest imaging and assay technologies applied to 3D microtissues

AUTOMATE

Scaffold-free 3D cell culture platforms – reliable ultra-low attachment and hanging drop platforms for automated microtissue production and assay

 

Your 3D InSight™ Conference Planner

Conference Dates 
23. - 27. January 2016

Venue
San Diego Convention Center

Booth
Meet InSphero 3D microtissue experts at Booth #307

Educational Events

Webinar 02 2015

Before the Conference
Watch our on-demand webinars to gain 3D Insight™ and make notes on questions to ask while you're at SLAS2016


Dr. Jens M. Kelm

Saturday, January 23, 8:30 AM - 4:30 PM
Register for a short course: 3D Cell-based Assays for Drug De-Risking led by Drs. Jens Kelm of InSphero, Ursula Graf-Hausner of the University of Applied Sciences Zurich, and Terry Riss of Promega Corporation

Monday, January 25, 1:00 - 3:00 PM
Visit Poster #2057: Multi-parametric 3D tumor microtissue-based phenotypic compound classification by Dr. Jens Kelm of InSphero (co-authored by NCATS/NIH). Poster Abstract: Phenotypic assays are a powerful tool in drug discovery. However, the predictive value of phenotypic drug testing depends on how close we can mimic the in vivo environment and the biomarker used to assess the clinical response. The closer we mimic the tissue environment and the respective disease progression the better the predictive value of an assay to discover and develop new therapeutics. 3D model systems can better reflect the cell composition, inter-cellular interaction, tissue structure, and biological characteristics of primary tumors. Here, we report on the development of homo- and heterotypic ovarian and pancreatic microtissue tumor models amenable for a screening assay of up to 40 compounds selected from the NCATS Oncology library. The compounds were chosen to target different mechanisms driving tumor cell growth and survival. The goal of this study was to develop a high throughput compatible drug screening assay based on 3D multicellular spheroids from ovarian (HEY-A8 and SKOV) and pancreatic (Panc-1) cancer which enables the discrimination of tumor-specific efficacy and unspecific cytotoxicity of a drug candidate with subsequent identification of the molecular mechanism of action (MMOA). The biological response measured over a 10-day drug exposure period included (i) growth kinetics (microtissue size), (ii) potency (IC50ATP_10_days) and efficacy (max. response ATP and size). The biological response of the compounds was compared between the different cell culture formats tested, 2D, 3D homotypic and 3D heterotypic. The comparison of IC50 values among the different ovarian cancer cell cultures showed that 21 out of the 38 compounds tested were more potent in 3D than in 2D. Within the pancreatic models, 13 out of 20 compounds tested were more potent in 3D than in 2D. Interestingly, most of the compounds which showed stronger potency in 3D were targeted small molecule agents. Comparing drug responses of homo vs heterotypic ovarian tumor model systems, 3 compounds were effective only in the heterotypic model including the WNT inhibitor PNU-74654 and GABA uptake inhibitor (Gat-1) SK&F-89976A. We also evaluated non-specific cytotoxic effects on the incorporated NIH3T3 fibroblasts by quantifying a secreted reporter over time. The assay system allowed us to discriminate between acute cytotoxic effects (3-day exposure) and sub-chronic toxicity (7-day exposure). Whereas only a very limited number of compounds had acute cytotoxic effects, there were considerable more compounds with sub-chronic cytotoxicity. Based on the single endpoint classifications, we choose an mTOR inhibitor, Torin-2, to further assess molecular mechanism of cell death action for all three tumor microtissue models used in this study using reversed phase protein assay and transcriptome analysis. In summary, we present a 3D tumor microtissue-based phenotypic drug discovery testing scheme which allows a multi-parametric endpoint analysis paired with subsequent molecular pathway identification.

 

Monday, January 25, 1:00 - 3:00 PM
Visit Poster #2189: Simplifying 3D microtissue-based screening using automation and image based cytometry on the EnSight multimode plate reader to generate and characterize scaffold-free 3D cell cultures, by Ann (Shang-pin) Kwei of PerkinElmer.  Poster Abstract:  3D cell culture spans the gap between the traditional “petri-dish-based” format and whole-animal systems by both mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, thus giving unique perspectives on tumorigenesis. Process standardization is essential to enable the generation of robust and reproducible data with more biologically relevant, but complex, 3D models. Here we demonstrate how producing and characterizing 3D spheroid microtissues with the InSphero GravityPLUS™ hanging drop microplate platform can be simplified and standardized by integrating automated liquid handlers with the EnSight™Multimode plate reader to reduce variability, hands-on time, and errors produced by manual pipetting. Process steps include: (i) using automation to generate hanging drop cultures in the InSphero GravityPLUS™ plate, (ii) automated transfer of the hanging drop cultures to the GravityTRAP™ ultra-low attachment plates for long-term growth, and (iii) automated media exchange and compound treatment in these plates. Tumor microtissue growth was assessed directly in the GravityTRAP™ plate using the imaging module of the EnSight™ plate reader and a custom-developed analysis procedure for basic 2D characterization that automatically identifies and measures spheroid area from brightfield images. This allows for rapid monitoring of tumor microtissue growth over time without necessitating addition of a fluorescent label. Tissue viability and proliferation was assessed further using the ATPlite™Luminescence Assay system in which spheroids are thoroughly lysed and ATP content assessed. Overall, a fully automated microtissue production and assay set-up is being presented to monitor growth and viability to further foster the use of more biologically relevant 3D models on an industrial scale.

 

Leena Mol Thuruthippillil

Monday, January 25, 2:00 - 2:45 PM
Attend a tutorial:  High-throughput, label-free phenotypic screening of tumor spheroid growth and morphology (featuring the SCREEN Cell 3iMager), led by Dr. Leena Mol Thuruthippallil of InSphero

 

DSi sm

Tuesday, January 26, 2:00 - 2:45 PM
Attend a tutorial: Advances in drug testing using scaffold-free 3D cell culture in automated high content screening systems, led by Dina Sirypangno of InSphero and Jacob Tesdorpf of PerkinElmer


SLAS2016 Preliminary Program

More information about SLAS2016

 

Learn from our experience — and win a Sphero 2.0!

sphero
Want to have your own remote-controlled spheroid? Attend one of our tutorials at SLAS2016 and you’ll be entered to win a Sphero 2.0 robotic toy. Attend both tutorials and double your chances of winning!

 

16.09.2013 - InSphero User Group Meeting, La Jolla, CA, USA

Predictive drug de-risking with 3D-cell-culture systems for new and experienced 3D microtissue users

InSphero’s fourth annual user group meetings in the US will bring together experts in efficacy and toxicology testing with 3D in vitro systems. This half-day event is a great educational and networking opportunity!

Preliminary program and registration information here.

Click to register now!

12.09.2013 - InSphero User Group Meeting, Cambridge, MA, USA

InSphero’s fourth annual user group meetings in the US will bring together experts in efficacy and toxicology testing with 3D in vitro systems. This half-day event is a great educational and networking opportunity!

Preliminary program and registration information here.

Click to register now!

03.07.-04.07.2013 - Cell Culture, London, UK

Meet the InSphero team at SMi's Cell Culture conference to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

  • InSphero booth in exhibition area
  • InSphero presentation "Discriminating drug effects in multi-cell type 3D cell culture models", DAY 1 from 11:00 AM to 11:40 AM, details in official program

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

30.06.-04.07.2013 - XIII International Congress of Toxicology (ICT 2013), Seoul, Korea

Meet the InSphero team at ICT 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

  • InSphero symposium presentation "A Novel Organotypic 3D Liver Model for Toxicity Studies", during session "3D goes 3R – complex in vitro methods for modern toxicity testing", check official program for details

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

23.06.-26.06.2013 - The European CLINAM & ETPN Summit: Clinical Nanomedicine & Targeted Medicine, Basel, Switzerland

Meet the InSphero team at CLINAM 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, can be used in clinical nanomedicine.

  • InSphero presentation "3D Liver Microtissues to Test Nanoparticle Toxicity", Wednesday, June 26, from 9:00 AM to 1:15 PM, during Satellite Session 2 organized by the Swiss competence centre TEDD
  • TEDD Satellite Session 2 "Tissue Engineering for Drug Development and Substance Testing", Wednesday, June 26, from 9:00 AM to 1:15 PM,find program and more than 50% discount for TEDD community

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

17.06.-18.06.2013 - BMS R&D Symposium, Princeton, NJ, USA

Visit the InSphero booth #400 (in Henry Hall) at BMS R&D Symposium to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

06.06-07.06.2013 - European Lab Automation 2013, Hamburg, Germany

Meet the InSphero team at ELA 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable affordable high-throughput screening in 3D.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

04.06.-06.06.2013 - World Pharma Congress, Philadelphia, PA, USA

Meet the InSphero team at WPC 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

29.05.2013 - InSphero User Group Meeting, Zurich, Switzerland

Predictive drug de-risking with 3D-cell-culture systems for new and experienced 3D microtissue users

InSphero’s third annual user group meeting in Zurich will bring together a growing number of experts in efficacy and toxicology testing with 3D in vitro systems. This full day event is a great educational and networking opportunity!

Program and registration information here.

New: InSphero Hands-on Training for 3D cell-based assays in our labs on May 28 and 30 - see next event/below!

28.05./30.05.2013 - InSphero Hands-on Training for 3D cell-based assays, Schlieren, Switzerland

New: InSphero Hands-on Training for 3D cell-based assays

Experience Insphero's Gravity-forced hanging-drop technology including production of microtissues, assay design and endpoint assays.

  • Tuesday 28 May or Thursday 30 May 2013, full-day
  • Venue: at InSphero laboratories in Schlieren, see address here
  • Registration fee: CHF 690 (places limited; 7 participants per day only)

Program

08:30-09:00 - Welcome reception

09:00-09:30 - Introduction to InSphero's assay-ready microtissues and platform for 3D cell culture

09:30–10:15 - Handling of GravityPLUS and GravityTRAP

10:15–10:45 - Medium manipulation – MT harvesting

10:45-11:00 - Coffee break

11:00-12:00 - Imaging of microtissues

12:00-13:00 - Lunch break

13:00-14:15 - Histology processing

14:15-15:30 - Biochemical endpoints

15:30-16:00 - Wrap-up, coffee and closing

15.05.-16.05.2013 - IVTIP Spring 2013 Meeting: State of the art on alternatives from industrial point of view: ready for regulation?, Southampton, UK

Visit the InSphero booth at IVTIP Spring 2013 Meeting to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

22.04.2013 - InSphero User Group Meeting, Munich, Germany

Zuverlässige Substanztestung in 3D-Zellkultursystemen
Predictive drug de-risking with 3D-cell-culture systems

This meeting is designed to bring you fully up to date on this hot topic with the latest information from experts in the use of 3D cell culture in efficacy and toxicology testing. Don't miss this great educational and networking opportunity!

Program and registration information here.

17.04.-19.04.2013 - Joint NEDMDG/ISSX Workshop: The Role of Druf Metabolism in Immune-Mediated Drug Toxicity - Molecular, Clinical and Mechanistic Aspects, Cambridge, MA, USA

Meet InSphero at the Joint NEDMDG/ISSX Workshop to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, can be used in your drug safety assessment.

To arrange a meeting on site or a webinar contact us: phone 207 751-4908.

Official workshop website.

06.04.-10.04.2013 - AACR 2013 Annual Meeting, Washington, DC, USA

Visit the InSphero booth at AACR 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

  • Booth number 603
  • Poster with Medical University Innsbruck "Development of an innovative 3D cell culture system to study tumor-stroma interactions in cancer cells", Tuesday, Apr 9 from 1:00 PM to 5:00 PM, abstract number 3840
  • Poster with Roche Glycart AG "Development of 3D microtissue models to study the activity of novel tumor-targeted immunotherapeutics", Tuesday, Apr 9 from 1:00 PM to 5:00 PM, abstract number LB-264
  • Poster with Helmholtz Zentrum München and Sirion Biotech "Identification of compounds modifying radiation-therapy using a 3D-microtissue technology", Wednesday, Apr 10 from 8:00 AM to 12:00 PM, abstract number 5528
  • Overview of InSphero activities at AACR 2013 download here

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Official conference website.

28.03.2013 - Boston-PBSS Seminar Luncheon: "Drug Induced Hepatotoxicity: Are We on the Right Track to Prediction? - A Clinical Perspective", Cambridge, MA, USA

Meet the InSphero team at Boston-PBSS Seminar Luncheon to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable affordable high-throughput screening in 3D.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

19.03.2013 - ELRIG Research & Innovation '13, Telford, UK

Meet the InSphero team at ELRIG.Research & Innovation to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable affordable high-throughput screening in 3D.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

15.03.2013 - Promega's Discover Glo with InSphero: Bioluminescent Cell-based Assay European Seminar Tour, Schlieren, Switzerland

Join InSphero and Promega for free presentations and discussions to learn more about cellular analysis, the latest developments and applications – and InSphero’s robust 3D cell-based assays.

Discover Glo: Bioluminescent Cell-based Assay European Seminar Tour

  • Friday 15 March 2013 from 14:30 PM - 17:00 PM
  • Presentations and networking opportunity
  • Cytos Auditorium, Wagistrasse 25, 8952 Schlieren
  • Free participation

View program and register here.

About the tour, more dates and locations, also in Basel and Lausanne.

10.03.-14.03.2013 - SOT 2013 52nd Annual Meeting & ToxExpo, San Antonio, TX, USA

Visit the InSphero booth or presentations at SOT 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

  • Booth number 1454
  • Exhibitor Hosted Session with Cyprotex and University of Berne "Advanced 3D-Cell Culture Models for Drug Safety Assessment", Wednesday, March 13 from 2:15 PM – 3:15 PM, Room 007 C, check official program for details
  • InSphero Beers & Spheres, Meet and Greet Happy Hour with Promega and CDI, Tuesday, March 12 from 7:30 PM, Casa Rio, 430 East Commerce Street, San Antonio
  • Poster presentation with Pfizer "A 3D co-culture model-based assay to assess liver Kupffer-cell activation and functionality", Tuesday, March 12 from 9:00 AM to 12:30 PM, abstract number 1072
  • Poster presentation with University of Berne "A human 3D myocardial microtissue model for cardiotoxicity testing", Tuesday, March 12 from 1:00 PM to 4:30 PM, abstract number 1476
  • Poster presentation by Michigan State University and CeeTox "Cytotoxic Interaction of Inflammagens with Trovafloxacin in Spheroid Cultures of Rat Liver Cells", Tuesday, March 12 from 9:00 AM to 12:30 PM, abstract number 1077

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

22.01.-23.01.2013 - CellTech2013, San Diego, CA, USA

Meet the InSphero team at CellTech2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable affordable high-throughput screening in 3D.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

12.01.-16.01.2013 - SLAS 2013 2nd Annual Conference & Exhibition, Orlando, FL, USA

Visit the InSphero booth or presentations at SLAS 2013 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, enable affordable high-throughput screening in 3D.

  • Booth number 2025
  • Short Course “3D Cell-Based Assays for Drug De-Risking”, Sunday, January 13, check official program for details
  • Podium presentation "Multiplexed drug assessment in multi-cell type 3D microtissues", part of session "Assays for Diverse Applications: Biologics, Diagnostics, and Toxicology", Wednesday, January 16 from 3:00 PM to 3:30 PM, Sun B, check official program for details
  • Poster presentation "Multi-cell Type Human Liver Microtissues for Hepatotoxicity Testing", displayed during session "Assay Development and Screening", Tuesday, January 15 from 1:00 PM to 3:00 PM

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it..

Official conference website.

18.06.-21.06.2012 - 2012 BIO International Convention, Boston, MA, USA

Meet the InSphero team at BIO Boston 2012 to learn how scaffold-free organotypic 3D microtissues, and 3D optimized assays, are boosting the process of drug discovery and development.

To arrange a meeting or a webinar please This email address is being protected from spambots. You need JavaScript enabled to view it.

Official conference website.

Company video

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