22.03.-26.03.2015 - SOT 2015 - San Diego, CA, USA

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Discover 3D Toxicity Testing Made Simple

Meet InSphero at Booth #2318

SOT2015 Invite 260x180  Download your InSphero guide to SOT 2015

Meet the InSphero team in San Diego at the 54th Society of Toxicology Annual Meeting and ToxExpoTM.  With eight postersthree exhibitor hosted sessions, and our bigger and better ToxExpo booth and Beers and Spheres Social, this year's meeting offers plenty of opportunities to learn more about our industry-leading 3D microtissue models for more predictive toxicity and safety testing, including: 

  • See how industry leaders including Genentech, AstraZeneca, Biognosys, and PerkinElmer are finding 3D InSightTM Liver Microtissues to be a superior model for assessing long-term toxicity, ADC-mediated toxicity, DILI predictivity, compound-treated proteomic profiling, transporter efflux activity and more.
  • Explore toxicity beyond the liver with 3D pancreatic microislet, cardiac, and neuronal models
  • Learn how we're partnering with industry leading cell based assay, proteomics, and imaging companies to ensure you can make the most of our 3D model systems with optimized protocols
  • Discuss how our 3D experts can customize a contract research project to meet your needs
  • Join us for our Beers and Spheres social - Monday, March 23 at 7:00 PM


Liver Microtissues

Human liver spheroid

Source: Human, rat, HepG2 and more

Pancreatic Microislets

Islet no background

 Source: Human, rat

Literature References

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Browse our latest publications


Poster Presentations

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Defeating the Animal: Alternative Systems for Neurotoxicity Testing
(presented by IfADo, Dortmund, Germany)
Abstract #248, Poster Board #414
Monday, March 23: 9:30 AM - 12:30 PM

Prodrug Activation in a Dynamic Microfluidics System Interconnecting Liver and Tumor Microtissues 
Abstract #449, Poster Board #136
Monday, March 23:  1:00 PM - 4:30 PM  

Standardized Rat and Human Microislets for Diabetes Research and Drug Safety Assessment
Abstract #1201, Poster Board #632
Tuesday, March 24: 9:00 AM - 12:30 PM

Evaluation of Spherical Liver Microtissues for In Vitro Cytotoxicity Assessment of Antibody-Drug Conjugates
(Presented by Genentech)
Abstract #892, Poster Board #115
Tuesday, March 24: 9:00 AM - 12:30 PM

Quantification of Efflux Transporter Activity in 3D Human Liver Microtissues
(Collaboration with PerkinElmer)
Abstract #2635, Poster Board #340
Thursday, March 26: 8:30 AM - 12:00 PM

Global Proteomic Profiling of Acetaminophen-Exposed 3D Human Liver Microtissues Identifies Novel NAPQI Adduct Sites
(Collaboration with Biognosys AG)
Abstract #2589, Poster Board #251
Thursday, March 26: 8:30 AM - 12:00 PM

Evaluation of the 3D InSightTM Human Liver Microtissues for the Detection of Compounds That Cause Drug-Induced Liver Injury in Humans
(Presented by AstraZeneca)
Abstract #2569, Poster Board #231
Thursday, March 26: 8:30 AM - 12:00 PM

Transmembrane Potential Measurements in Cardiac Microtissues Derived from Human Stem Cells
(Presented by University of Glasgow)
Abstract #2840, Poster Board #659
Thursday, March 26: 8:30 AM - 12:00 PM

Modifications Required for ATP and Caspase Detection Assays Applied to 3D Cell Spheroids
(Presented by Promega Corp.)
Abstract #2577, Poster Board #239
Thursday, March 26: 8:30 AM - 12:00 PM


Exhibitor Hosted Sessions

SLAS Tutorial

Join us for free continental breakfast!
3D microtissue cultures: use in long-term hepatocyte ADME-Tox studies

Co-presented with BioreclamationIVT
Monday, March 23
9:15 AM - 10:15 AM
Room 24B

InSphero and BioreclamationIVT present the latest data on the characterization of 3D human liver microtissues and their application to toxicity testing, drug metabolism studies and disease modelling. In addition, the attendees will learn about donor-to-donor differences and the use of liver non-parenchymal cells for 3D liver cultures.


3D microtissues meet OMICS technologies and high-content imaging
Monday, March 23
3:15 PM - 4:15 PM
Room 24C

OMICS technologies and high-content imaging have been demonstrated to be valuable tools to unravel biological pathways and phenotypic outcomes. This session aims to introduce the use of confocal imaging techniques, transcriptomics and proteomics in combination with organotypic 3D model systems to assess toxicological pathways and mechanisms.


3D liver models and beyond: 3D hepatic, cardiac, pancreatic, and neural microtissue models for toxicity testing
Tuesday, March 24
2:30 PM - 3:30 PM
Room 24C

3D liver microtissue models have demonstrated significant value as more organotypic systems for assessment of toxicity.  This session aims to cover the latest studies characterizing 3D InSight™ liver microtissues, and introduce novel 3D models for assessment of toxicity in non-liver organs, focusing on the heart, pancreas, and brain.   

Join us for cocktails at our 'Beers and Spheres' Event

Co-hosted by Promega and Cellular Dynamics International

Monday, March 23 7:00 PM - 10:00 PM
Don Chido - San Diego Gaslamp
527 5th Avenue
San Diego, CA 92101
Click for map


Register at the official meeting site.

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