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NIH/NCATS and InSphero Host Inaugural 3D Tumor Model Standards Working Group at AACR 2017

NIH/NCATS and InSphero Host Inaugural 3D Tumor Model Standards Working Group at AACR 2017

Establishing standards for next-generation tumor models to benefit drug discovery and broader research community primary objective of new group. PDF Vesion

Schlieren, Switzerland - April 18, 2017

The inaugural meeting of the 3D Standards Working Group was held during the American Association of Cancer Research (AACR) Annual Meeting in Washington, DC, on Saturday, April 1.  Organized and hosted by the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, and InSphero AG, the meeting drew representatives from academic institutions, pharmaceutical and life sciences industries, as well as government agencies, to discuss the use of 3D cancer models within drug discovery campaigns, and review biological and technical requirements needed for the next generation of high-throughput screening-compatible (HTS) models.

"There is a growing need for in vitro 3D tumor models that mimic in vivo tumor physiology for more efficient cancer drug discovery,” says InSphero Chief Scientific Officer Dr. Patrick Guye. “We sought to bring together key opinion leaders in academia, industry and government to develop guidelines that we believe are critical to establish 3D tumor models as a highly predictive platform for therapeutic drug development assays.” The group plans to publish its findings and recommendations for developing and using 3D tumor models for drug development, with the intent to make the best consensus information available to the broader research community.

“We made tremendous progress during this kickoff meeting,” says Dr. Madhu Lal Nag, Head of the Trans NIH RNAi Facility at NCATS. “We not only discussed where we stand today, with regard to developing advanced 3D models that capture the complexity of the tumor microenvironment, but also delved into needs for standardized nomenclature, benchmarking, improved model predictivity, and multiparametric readouts.” Going forward, the group plans to meet quarterly by teleconference and in person during future conferences, such as AACR, which most members of the working group attend.

For more information about NCATS, visit https://ncats.nih.gov.

For more information about InSphero, visit www.insphero.com

InSphero contacts

Dr. Randy Strube
Director of Global Marketing
Phone +1 800-779-7558 ext. 102
This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Patrick Guye
Chief Scientific Officer
Phone +41 44 5150490
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

About InSphero

InSphero sets the standard for in vitro testing of novel drugs in the pharmaceutical and biotechnology industry with comprehensive solutions that provide greater confidence in decision making. Its robust and highly physiologically relevant suite of 3D InSight™ Microtissues and Services are used by major pharmaceutical companies worldwide to increase efficiency in drug discovery and safety testing. InSphero patent-pending technologies and methods enable large-scale, reproducible production of scaffold-free 3D microtissues (spheroids) driven solely by cellular self-assembly. The company specializes in delivering assay-ready and custom 3D models derived from liver, pancreas, and tumor tissues, to provide unrivalled biological insight into liver toxicology, metabolic diseases (e.g., diabetes and liver diseases), and oncology (with a focus on immuno-oncology). All InSphero microtissues are thoroughly validated to ensure the highest quality, certified for use in a variety of assays, and shipped globally to customers in a patented, easy-to-use spheroid-optimized platform, ready for research. Field application scientists and research staff with expertise in working with 3D models help ensure efficient integration and onsite training as needed. For customers who prefer an outsourcing strategy with fast turnaround, InSphero also offers contract research services utilizing their 3D microtissue models.

InSphero 3D InSight™ solutions drive significant findings in peer-reviewed journals, through collaborative industry initiatives such as EU-ToxRisk and HeCaToS, and have gained validation in the world’s largest government institutions and pharmaceutical, chemical and cosmetics companies.

Founded in 2009, the privately held company is headquartered in Schlieren, Switzerland with subsidiaries in the United States (Brunswick, ME) and Waldshut, Germany. It has been recognized for its scientific and commercial achievements with several national and international awards.

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InSphero Wins "Best Technology" Award at ELRIG Research and Innovation Conference

InSphero 3D InSight™ Microtissues Win "Best Technology" Award at ELRIG Research and Innovation Meeting 

Schlieren, Switzerland - March 31, 2017 #ELRIGRI17

InSphero was announced on Thursday as winner of the ELRIG Research & Innovation "Best Technology" Award, recognizing an innovative portfolio of advanced 3D InSight™ Microtissues for drug safety and efficacy testing.  The honor was awarded based on voting by attendees at the annual meeting, held this week at Homerton College in Cambridge, UK.

Amongst the topics of the 2017 scientific program were sessions on the scale-up of physiologically relevant 3D models, as well as innovative technologies for immuno-oncology and immunotherapy. InSphero's patent pending 3D Select™ Process enables industry-scale production of liver, pancreatic islet, and tumor microtissues that more accurately reflect in vivo tissue. InSphero's more physiologically relevant liver microtissues provide a more sensitive and highly specific in vitro model for predicting drug-induced liver injury, while islet and tumor microtissues are advanced models for diabetes and oncology drug discovery. InSphero will present its latest advances in the application of complex 3D tumor/stromal/immune co-culture microtissues for immuno-oncology drug development at next week's American Association of Cancer Research (AACR) Meeting in Washington, DC

Dr. Adrian Rea, who with Dr. Andrea Lindemann accepted the award on behalf of InSphero, stated "We're hononored that our technology was recognized by the attendees at this year's ELRIG Research & Innovation Meeting. We enjoyed the opportunity to discuss the scientific benefits our microtissues have to offer with the attendees, and in turn learn from them about emerging trends in these exciting fields during the scientific sessions" 

 

InSphero contacts

Dr. Randy Strube
Director of Global Marketing
Phone +1 800-779-7558 ext. 102
This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Jan Lichtenberg
Chief Executive Officer, Co-founder
Phone +41 44 5150490
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

About InSphero

InSphero provides superior biological relevance to in vitro testing with its easy-to-use solutions for production, culture and assessment of organotypic 3D cell culture models. The company’s patented technologies include the 3D Select™ Process (pending) and scaffold-free 3D cell culture plates that enable large-scale, reproducible production of a broad range of assay-ready 3D InSight™ Microtissues derived from liver, pancreas, and tumors. These models and contract research services utilizing them help to identify promising drugs and toxic liabilities with greater predictive power at early development stages, enabling better pre-clinical decision making, saving development cost, and shortening time to market. InSphero technologies drive significant findings in peer-reviewed journals, through collaborative projects such as EU-ToxRisk and HeCaToS, and have gained validation in the world’s largest government institutions and pharmaceutical, chemical and cosmetics companies. This 3D know-how is also being applied in the diagnostics field to aid development of personalized chemotherapeutic strategies for the treatment of cancer.

Founded in 2009, the privately held company is headquartered in Schlieren, Switzerland with subsidiaries in the United States (Brunswick, ME) and Waldshut, Germany. It has been recognized for its scientific and commercial achievements with several national and international awards.

Follow us on Twitter and and LinkedIn, and visit www.insphero.com.

 

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InSphero Liver Microtissue

InSphero 3D InSight™ Human Liver Microtissues provide greater confidence to pharmaceutical drug discovery and development groups in their efforts to predict drug-induced liver injury in vitro prior to testing in animals or patients.

Novel 3D Cell-based Assays Accelerate Discovery for Immuno-oncology/CAR-T Therapies

Novel 3D Cell-based Assays Accelerate Discovery for Immuno-oncology/CAR-T Therapies 

InSphero presents latest data demonstrating immune cell interaction with 3D tumor models for in vitro efficacy testing of oncology drugs and immunotherapies at AACR.  PDF Version

Schlieren, Switzerland - April 03, 2017 –  InSphero AG highlighted the unique advantages of its physiologically relevant 3D InSight™ Microtissue Platform to drive more efficient development of anti-cancer drugs and immuno-oncology (I-O) approaches at the American Association of Cancer Research (AACR) Annual Meeting in Washington, DC. The presentations included data generated in collaboration with academic, government, and industry partners.

“Our presentations at this year’s AACR meeting display not only the variety and complexity of tumor models we can produce through our Custom Tumor Microtissue Development Service, but also the breadth of applications for which they can be used throughout the drug development pipeline,“ said Dr. Jens Kelm, InSphero Chief Technology Officer and Co-founder. “These range from early discovery screens in cell-line based 3D microtissue models in 384-well format to more complex pre-clinical development and validation studies, using co-cultures of fibroblasts with cancer cell lines or patient-derived xenograft (PDX) samples.”

In addition, InSphero presented data demonstrating the infiltration of activated immune cells, such as peripheral blood mononuclear cells (PBMCs), into tumor-stromal co-culture models. “Recent successes in I-O therapies for blood-borne cancers has triggered the race in pharma for similar strategies targeting solid tumors,” Dr. Kelm said. “Our technology provides the first turnkey 3D platform for mimicking complex solid tumor environments in vitro. It is designed specifically for the development and optimization of CAR-T, CAR-NK, or immunomodulatory based I-O strategies.” InSphero scientists recently showed that activated PBMCs can penetrate tumor-stromal microtissues and specifically kill tumor cells. The findings were published in a collaborative study with Roche Pharmaceutical and ETH Zurich in the January 2017 issue of the journal Cancer Immunology, Immunotherapy.

“We have presented work done in collaboration with the University of Zurich as well, where we’ve created microtissues directly from patient tumor biopsy material,” Dr. Kelm said. “This approach holds potential for in vitro testing in the clinical phase to help identify a personalized treatment plan using drugs most effective against the biopsied material cultured in 3D.”

In addition to custom model development, InSphero offers 3D InSight™ Oncology Services, including single or combinatorial drug testing, tumor relapse, and antibody penetration assays, all of which can be conducted on customized tumor microtissues, or on established tumor-stromal co-culture models. 

InSphero AACR Poster Presentations

Wednesday, April 5 (8 AM – 12 PM)
Poster 5781/17 (Section 38): Establishment of a 3Dex vivoassay as a preclinical drug testing platform for personalized cancer therapy. Presented by Dr. Sumeer Dhar, InSphero AG (collaboration with University of Zurich).

Wednesday, April 5 (8 AM – 12 PM)
5780/16 (Section 38): 3Dex vivoassay platform using primary lung cancer cells in malignant pleural effusions as predictors for clinical outcome of personalized chemotherapy.Presented by Cheng-guang Wu, University of Zurich (collaboration with InSphero AG).

In-booth Poster Presentations

Booth 1029 (Sunday 12 PM – Wednesday 12 PM, during exhibition hours)
- Evaluation of immuno-therapeutic efficacy in biologically relevant 3D tumor microtissue models
- InSphero’s oncology platform for accelerating drug discovery and development

For more information about InSphero 3D InSight™ solutions for oncology, visit www.insphero.com.

 

InSphero contacts

Dr. Randy Strube
Director of Global Marketing
Phone +1 800-779-7558 ext. 102
This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Jens M. Kelm
Chief Technology Officer, Co-founder
Phone +41 44 5150490
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

About InSphero

InSphero provides superior biological relevance to in vitro testing with its easy-to-use solutions for production, culture and assessment of organotypic 3D cell culture models. The company’s patented technologies include the 3D Select™ Process (pending) and scaffold-free 3D cell culture plates that enable large-scale, reproducible production of a broad range of assay-ready 3D InSight™ Microtissues derived from liver, pancreas, and tumors. These models and contract research services utilizing them help to identify promising drugs and toxic liabilities with greater predictive power at early development stages, enabling better pre-clinical decision making, saving development cost, and shortening time to market. InSphero technologies drive significant findings in peer-reviewed journals, through collaborative projects such as EU-ToxRisk and HeCaToS, and have gained validation in the world’s largest government institutions and pharmaceutical, chemical and cosmetics companies. This 3D know-how is also being applied in the diagnostics field to aid development of personalized chemotherapeutic strategies for the treatment of cancer.

Founded in 2009, the privately held company is headquartered in Schlieren, Switzerland with subsidiaries in the United States (Brunswick, ME) and Waldshut, Germany. It has been recognized for its scientific and commercial achievements with several national and international awards.

Follow us on Twitter and and LinkedIn, and visit www.insphero.com.

 

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