3D InSight™ Testing Services

In vitro toxicology and drug discovery services in advanced 3D microtissue models

Early compound de-risking and drug discovery decisions require in vitro data with the highest possible biological relevance. 3D InSight™ Services utilize next-generation 3D models to answer the most pressing questions about the safety and effectiveness of your drug, helping you make pre-clinical decisions with greater confidence. Our experienced staff of 3D scientists can plan, conduct and interpret a tailored screening project using biologically relevant 3D models at a fraction of the cost of animal testing and human trials.  With our custom microtissue development service, we can also help you establish and validate a novel spheroid model system using your cell lines of interest.

Our 3D InSight™ Services feature:

  • Organotypic, standardized 3D microtissue models for liver, tumor, pancreatic islets, and other biological systems
  • Rapid turnaround to keep your project moving forward with results from more physiologically relevant models
  • Fully customizable experimental design to expand beyond standard testing results
  • Strict confidentiality between our 3D experts and your project team
  • Thorough consultation and reporting from proposal to project completion

 

3D InSight™ In Vitro Toxicology Services

Hepatotoxicity Testing

3D InSight™ Hepatotoxicity Testing

InSphero offers several convenient options for hepatotoxicity testing using our next-generation 3D InSight™ Liver Microtissues, which are developed using human or animal primary hepatocytes, co-cultured with non-parenchymal cells. Our standard services enable you to leverage the enhanced sensitivity and specificity of long-term (7-14 day) compound exposure, with protocols enabled by the improved longevity of primary hepatocytes when cultured in a scaffold-free 3D format.

Model systems employed

Services offered

Mitochondrial Toxicity Testing

3D InSight™ Mitochondrial Toxicity Testing

Leverage advanced, organotypic 3D liver microtissues to assess mitochondrial liabilities using the Agilent XFe96 Analyzer.

Model systems employed

Services offered

Embryotoxicity (DART) Testing

3D InSight™ Embryotoxicity Testing 

A reliable embryotoxicity screening service for in vitro developmental and reproductive toxicity (DART) testing

Model system employed

  • Embryoid bodies (EBs) derived from ESD3 cells

Services offered

3D InSight™ Drug Discovery Services


Oncology

3D InSight™ Oncology Services

Tumor microtissue-based efficacy testing from the experts in 3D

  • Conduct your study in organotypic 3D tumor and tumor/stromal models
  • Enable long-term, repeat-dose experiments with 3D-optimized endpoints
  • Utilize standardized protocols for compound testing and classification
  • Receive rapid turnaround with strict confidentiality

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