3D InSight™ Oncology Services

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Tumor microtissue-based efficacy testing from the experts in 3D

  • Conduct your study in organotypic 3D tumor and tumor/stromal models
  • Enable long-term, repeat-dose experiments with 3D-optimized endpoints
  • Utilize standardized protocols for compound testing and classification
  • Receive rapid turnaround with strict confidentiality
 

Leverage 3D models and expertise for more biologically relevant drug discovery

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You've identified drugs that are effective against tumor cells in monolayer culture, but now what? How effective are they at inhibiting the growth in a more complex 3D tumor spheroid model? Do they work better alone or in combination with other drugs? How will a tumor respond in the absence of a drug following initial treatment? If it's a biologic, can it penetrate solid tumor tissue, or would re-engineering improve its efficacy?

3D InSight™ custom tumor microtissues enable the development of novel in vitro assays for compound classification. InSphero has established a set of assays not only to evaluate efficacy and potency of compounds in a more physiologically relevant in vitro model, but also to assess the probability of tumor relapse. All assays are designed to "plug-and-play" with 3D InSight™ tumor models derived from cell lines or primary cell sources. If you lack the time or resources to implement 3D testing into your oncology workflow, entrust InSphero experts to deliver experimental results in 3D.

 

  • 3D InSight™ Custom Tumor Microtissues

    Whether you work with common or modified immortalized cell lines, PDX tumor cell lines, or complex co-cultures, we can help build the right tumor model for your study. InSphero scientists have optimized the cell culture conditions that enable reliable production of a 3D tumor microtissues from a variety of cancer cell lines to effectively recapitulate the tumor microenvironment. Our Custom Tumor Microtissue Development Services team can prepare 3D InSight™ tumor models from a single cancer cell type or using more complex co-cultures with fibroblasts (NIH3T3 or NHDF), with or without HUVECs. The following table lists some of the many cancer cell lines that our scientists have used to create 3D tumor models.

    Tumor Type Cancer Cell Lines
    Lung A549, Colo699
    Liver HepG2, Huh-7
    Colorectal HCT-116, HT-29, DLD-1, LS174T, LoVo
    Breast MCF-7, T47D, MDA-MB-231, MDA-MB-361
    Prostate DU-145, PC-3
    Glioblastoma SNB-19, LN-18
    Ovarian A2780, HEY
    Cervical C33-A
    Kidney A498, 786-O
    Osteosarcoma SAOS-2, HOS, MG-63

     

    MT models

 

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