3D InSight™ In Vitro Toxicology Services

Extend your scientific staff with in vitro toxicology services based on advanced 3D tissue models

Our 3D InSight™ In Vitro Toxicology Services combine the predictive power of our proprietary 3D microtissues with the professional expertise of our scientific staff, and advanced 3D-optimized assay protocols. We’ve partnered with gold-standard assay providers to develop convenient, standardized service offerings for hepatotoxicity, mitotoxicity, and embryotoxicity. Our scientists offer years of experience in drug safety testing, and are focused on helping you solve your particular challenge using 3D in vitro models to better predict Drug Induced Liver Injury (DILI), investigate troublesome compounds through mechanistic studies, accelerate drug repurposing, and begin accumulating toxicity data during early discovery using cost-effective, organotypic scaffold-free 3D cell culture models.

In vitro toxicology services offered:

Hepatotoxicity Testing

3D InSight™ Hepatotoxicity Testing

InSphero offers several convenient options for hepatotoxicity testing using our next-generation 3D InSight™ Liver Microtissues, which are developed using human or animal primary hepatocytes, co-cultured with non-parenchymal cells. Our standard services enable you to leverage the enhanced sensitivity and specificity of long-term (7-14 day) compound exposure, with protocols enabled by the improved longevity of primary hepatocytes when cultured in a scaffold-free 3D format.

Model systems employed

Services offered

Mitochondrial Toxicity Testing

3D InSight™ Mitochondrial Toxicity Testing

Leverage advanced, organotypic 3D liver microtissues to assess mitochondrial liabilities using the Agilent XFe96 Analyzer.

Model systems employed

Services offered

Embryotoxicity (DART) Testing

3D InSight™ Embryotoxicity Testing 

A reliable embryotoxicity screening service for in vitro developmental and reproductive toxicity (DART) testing

Model system employed

  • Embryoid bodies (EBs) derived from ESD3 cells

Services offered

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