Evaluate pre-clinical species-specific drug effects in vitro using organotypic 3D liver microtissues
- Compare drug-induced liver injury (DILI) in 3D primary liver microtissue models from human, rat, dog, and monkey
- Perform translational toxicity studies in advanced 3D liver models using a standardized 7 day, repeat-dosing protocol
- Normalize differential drug/media-component binding effects with a universal testing medium used for all species
Service at a Glance(View as a PDF)
Determine the models in which you want to compare the effect of your drug(s). Choose from advanced 3D liver microtissue models derived from primary rat, dog, monkey, or human hepatocytes.
Dose-response curves for Sitaxsentan generated using ATP cell viability assay following 7-day treatment of human, dog, monkey, and rat liver microtissues demonstrating species-specific hepatotoxicity profiles.
Additional endpoints which are compatible with the standard assay setup to support customized translational and mechanistic toxicological queries.