Primary cynomolgus hepatocyte-derived 3D monkey liver models delivering greater physiological relevance for investigative toxicology studies
3D InSight™ Monkey Liver Microtissues are standardized, functional 3D liver spheroids derived from primary cynomolgus hepatocytes. They are delivered assay-ready for studying species-specific effects of liver function and toxicity.
- De-risk and improve the success rate of your animal studies by pre-testing in a species-specific in vitro model that reflects in vivo biology
- Perform chronic toxicity testing with long-term treatments in a model with a culture lifetime of 28 days, 4x that of conventional 2D cell culture (7 days)
- Use a physiologically relevant in vitro model exhibiting polarization of hepatocytes, formation of bile canaliculi, and functional cytochrome P450 activity
|Designed for the assessment of:||Options|
|Short-term, acute toxicity (2-7 days)||● ●|
|Long-term, chronic toxicity (14 days)||● ●|
|Species-specific toxicity||● ●|
|Inflammation-mediated toxicity||● ●|
Microtissue size and morphology is stable for more than 28 days when cultured in GravityTRAP™ plates with our specially formulated media.
Our organotypic 3D Monkey liver model. 3D InSight™ Monkey Liver Microtissues are composed of primary cynomolgus hepatocytes, and available in monoculture or in co-culture with human Kupffer cells.
Preserved viability. 3D InSight™ Monkey Liver Microtissues are viable for more than 28 days in culture, as demonstrated by stable ATP content (shown in pmol/microtissue), evaluated by CellTiter-Glo® ATP-assay (Promega).
Robust functionality for more than 28 days in culture. Albumin secretion was used as a measure of hepatocyte functionality (shown in μg/106 cells/day)