3D InSight™ Monkey Liver Microtissues

Primary cynomolgus hepatocyte-derived 3D monkey liver models delivering greater physiological relevance for investigative toxicology studies

3D InSight™ Monkey Liver Microtissue models

3D InSight™ Monkey Liver Microtissues are standardized, functional 3D liver spheroids derived from primary cynomolgus hepatocytes. They are delivered assay-ready for studying species-specific effects of liver function and toxicity.

  • De-risk and improve the success rate of your animal studies by pre-testing in a species-specific in vitro model that reflects in vivo biology
  • Perform chronic toxicity testing with long-term treatments in a model with a culture lifetime of 28 days, 4x that of conventional 2D cell culture (7 days)
  • Use a physiologically relevant in vitro model exhibiting polarization of hepatocytes, formation of bile canaliculi, and functional cytochrome P450 activity

 

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Designed for the assessment of: Options
Short-term, acute toxicity (2-7 days)   ●   
Long-term, chronic toxicity (14 days)   ●   
Species-specific toxicity   ●   
Inflammation-mediated toxicity   ●   
Microtissues     Service

 


learn more about Monkey Liver Microtissues quote

 

  •  monkey liver microtissue morphology

    Microtissue size and morphology is stable for more than 28 days when cultured in GravityTRAP™ plates with our specially formulated media. 

  • monkey liver organotypic modelOur organotypic 3D Monkey liver model. 3D InSight™ Monkey Liver Microtissues are composed of primary cynomolgus hepatocytes, and available in monoculture or in co-culture with human Kupffer cells. 

  • monkey liver microtissue viability

    Preserved viability. 3D InSight™ Monkey Liver Microtissues are viable for more than 28 days in culture, as demonstrated by stable ATP content (shown in pmol/microtissue), evaluated by CellTiter-Glo® ATP-assay (Promega).

     

     

     

     

  • monkey liver microtissue functionalityRobust functionality for more than 28 days in culture.  Albumin secretion was used as a measure of hepatocyte functionality (shown in μg/106 cells/day)

  • Stable morphology over time
  • 3D model reflects in vivo liver-specific morphology
  • Long-term viability enables long-term hepatotoxicity testing
  • Long-term functionality ensures reliable results over time

 

 

3D InSight™ Monkey Liver Microtissues
Production lead time: 2 weeks for US orders, ROW please inquire

Place your order on Tuesday at 6 PM (CET) two weeks before your desired ship date based on our production schedule. (Please indicate your desired ship date when requesting a quote.) For more detailed information about the order and shipment dates for all InSphero microtissue products, please see our quarterly production schedule.

Catalog # Description
MT-02-007-01 3D InSight™ Monkey Liver Microtissues from primary hepatocytes, monoculture (96x)
MT-02-007-04 3D InSight™ Monkey Liver Microtissues from primary hepatocytes, co-culture with human Kupffer cells (96x)
CS-07-004 Maintenance Medium - AF for Monkey Liver 500 mL*
AK-01-001-01 Cytotoxicity Assay Kit (for up to 4 96-well plates)

*only available together with 3D InSight™ Microtissues

 

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