3D InSight™ Pancreatic Islet Microtissues

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3D Insight Pancreatic Islet Microtissues

Standardized pancreatic islet microtissues

3D InSight™ Islet Microtissues are uniform, functionally robust, and long-lived primary islets delivered pre-qualified and assay-ready for studying islet function, regeneration and preservation.

  • Eliminate native islet variability using standardized islets, uniform in size, cellular composition and function
  • Expand your assay window with islet microtissues displaying an average 13-fold glucose-stimulated insulin secretion for more than 28 days in culture
  • Use a physiologically relevant in vitro model reflecting in vivo dynamics of insulin release and native tissue architecture
  • Stop hand-picking islets and substantially reduce assay-handling time with the convenience of validated islets delivered to your lab in a user-friendly, automation-compatible format



Certified Applications

Designed for the assessment of: Options
β-cell function and insulin secretagogues
α-cell function and glucagon suppressors
Islet viability and apoptosis
β-cell proliferation
β-cell function under stress
  • Glucotoxicity
  • Glucolipotoxicity
  • Cytokine induced injury
  • Immune cell co-culture

Dynamic insulin secretion with perifusion
Ca2+ oscillations
Drug safety – drug-induced pancreatic endocrine injury
Microtissues     Service     Technical Protocol


Uniform pancreatic islet microtissues

 Learn more in our White Paper

Islet White Paper


3D Select Process for Pancreatic Islet Microtissues
Insulin | Glucagon | Somatostatin

Production of 3D InSight™ Islet Microtissues starts with fine-tuned dissociation of primary donor islets, followed by controlled scaffold-free cellular reassembly and maturation in customized media that support maximum survival and optimal metabolic functionality of highly sensitive primary islet cells. The resulting uniform islets provide minimal intra-assay and intra-donor variability, while sustaining robust and long-term function.

Ordering Information

InSphero 3D InSight™ Human Islet Microtissue production is dependent on donor availability. Place your order on or before Tuesday at 6 PM CET (12 PM EST) to have your microtissues ship based on the below production schedule. 3D InSight™ Human Islet Microtissues are shipped to customers in the United States and Europe. For pricing information and shipping costs, please request a quote.

Catalog # Description Order by ► Ships on: US | EU
MT-04-002-01 3D InSight™ Human Islet Microtissues (96x) Oct 10 ► Oct 17 | Oct 18
Oct 17 ► Oct 24 | Oct 25
Oct 24 ► Oct 31 | Nov 01
For future production runs, please This email address is being protected from spambots. You need JavaScript enabled to view it..
CS-07-005-01* Human Islet Maintenance Medium, 500 mL  
MT-04-001-01 3D InSight™ Rat Islet Microtissues (96x)
CS-07-006-01* Rat Islet Maintenance Medium, 500 mL  

 * Available only when purchased with 3D InSight™ Islet Microtissues.


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