Resources

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids

Three-dimensional renal organoids from whole kidney cells: generation, optimization, and potential application in nephrotoxicology in vitro

3D Cell Culture for Compound De-Risking

Microscale tissue engineering using gravity-enforced cell assembly

A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-Assembly of Microtissue Building Blocks

Scaffold-free cell delivery for use in regenerative medicine

Heterologous Protein Production Capacity of Mammalian Cells in 2D and 3D cultures

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

Patient-derived tumor spheroid cultures as a promising tool to assist personalized therapeutic decisions in breast cancer

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a -Adrenoreceptor-Dependent Mechanism

Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors

miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages

Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro

In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening

Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis

Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine

An in vitro osteosarcoma 3D microtissue model for drug development

Evaluation of assays for drug efficacy in a three-dimensional model of the lung

Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo

High-throughput imaging: Focusing in on drug discovery in 3D

Development of an innovative 3D cell culture system to study tumour–stroma interactions in non-small cell lung cancer cells

Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues

3D cell culture systems modeling tumor growth determinants in cancer target discovery

Hepatic toxicology following single and multiple exposure of nanomaterials utilising a novel primary human 3D liver microtissue model

A High-Throughput–Compatible 3D Microtissue Co-culture System for Phenotypic RNAi Screening Applications

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System

Cell culture: A better brew

Multi-cell type human liver microtissues for hepatotoxicity testing

A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery

A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment

Translational Safety: The Next Frontier for 3D In Vitro Liver Toxicity Testing

The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

Transcriptomic, Proteomic, and Functional Long-term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Multiplexed Drug Assessment in 3D. Combining Luminescence and Fluorescence Genetic Reporters to Assess Drug Effects

Characterization and Drug Sensitivity Testing of HTS-Compatible Cancer Microtissues

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Expression Analysis of Exosomal MicroRNAs in Chlorpromazine Treated Human Hepatic Spheroids: A Promising Tool for Novel Drug-Induced Liver Injury Biomarker Discovery

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes

Tracing Clonal Dynamics Reveals that Two-and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma

Effect of IL4 and IL10 on a human in vitro type 1 diabetes model

Special Report on Cancer: Aiming for Avatars

Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes

HIF-1alpha inhibitor PX-478 preserves pancreatic beta cell function in diabetes

Translational assessment of a genetic engineering methodology to improve islet function for transplantation

A microfluidic hanging-drop-based islet perifusion system for studying glucose-stimulated insulin secretion from multiple individual pancreatic islets

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution

Targeted pharmacological therapy restores β-cell function for diabetes remission

Glucose, Adrenaline and Palmitate antagonistically regulate insulin and glucagon secretion in human pseuodislets

Modelling the endocrine pancreas in health and disease

Targeted delivery of antisense oligonucleotides to pancreatic β-cells

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Multifunctional in vivo imaging of pancreatic islets during diabetes development

Considerations for engineering composable, disease-tunable 3D human microtissues for drug discovery

Identification of proliferative and mature ß-cells in the islets of Langerhans

Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis

Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets

Tubing-free microfluidic microtissue culture system featuring gradual, in vivo-like substance exposure profiles

Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models

Microfluidic Hydrogel Hanging‐Drop Network for Long‐Term Culturing of 3D Microtissues and Simultaneous High‐Resolution Imaging

Electrical impedance spectroscopy for microtissue spheroid analysis in hanging-drop networks

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

Automated, multiplexed electrical impedance spectroscopy platform for continuous monitoring of microtissue spheroids

Adding the “heart” to hanging drop networks for microphysiological multi-tissue experiments

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

96-well format microfluidic platform for parallel interconnection of multiple multicellular spheroids

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

Experimental Program Design Considerations for Optimized Use of Preclinical Models in NASH Drug Discovery

Evolving Models for NASH Drug Discovery

Evaluation of human liver microtissues for drug screening on schistosoma mansoni schistosomula

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation

Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype

Predicting Metabolism-Related Drug–Drug Interactions Using a Microphysiological Multitissue System

Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro

Resources

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids

Three-dimensional renal organoids from whole kidney cells: generation, optimization, and potential application in nephrotoxicology in vitro

3D Cell Culture for Compound De-Risking

Microscale tissue engineering using gravity-enforced cell assembly

A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-Assembly of Microtissue Building Blocks

Scaffold-free cell delivery for use in regenerative medicine

Heterologous Protein Production Capacity of Mammalian Cells in 2D and 3D cultures

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

Patient-derived tumor spheroid cultures as a promising tool to assist personalized therapeutic decisions in breast cancer

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a -Adrenoreceptor-Dependent Mechanism

Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors

miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages

Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro

In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening

Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis

Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine

An in vitro osteosarcoma 3D microtissue model for drug development

Evaluation of assays for drug efficacy in a three-dimensional model of the lung

Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo

High-throughput imaging: Focusing in on drug discovery in 3D

Development of an innovative 3D cell culture system to study tumour–stroma interactions in non-small cell lung cancer cells

Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues

3D cell culture systems modeling tumor growth determinants in cancer target discovery

Hepatic toxicology following single and multiple exposure of nanomaterials utilising a novel primary human 3D liver microtissue model

A High-Throughput–Compatible 3D Microtissue Co-culture System for Phenotypic RNAi Screening Applications

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System

Cell culture: A better brew

Multi-cell type human liver microtissues for hepatotoxicity testing

A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery

A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment

Translational Safety: The Next Frontier for 3D In Vitro Liver Toxicity Testing

The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

Transcriptomic, Proteomic, and Functional Long-term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Multiplexed Drug Assessment in 3D. Combining Luminescence and Fluorescence Genetic Reporters to Assess Drug Effects

Characterization and Drug Sensitivity Testing of HTS-Compatible Cancer Microtissues

Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types

Expression Analysis of Exosomal MicroRNAs in Chlorpromazine Treated Human Hepatic Spheroids: A Promising Tool for Novel Drug-Induced Liver Injury Biomarker Discovery

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes

Tracing Clonal Dynamics Reveals that Two-and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma

Effect of IL4 and IL10 on a human in vitro type 1 diabetes model

Special Report on Cancer: Aiming for Avatars

Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes

HIF-1alpha inhibitor PX-478 preserves pancreatic beta cell function in diabetes

Translational assessment of a genetic engineering methodology to improve islet function for transplantation

A microfluidic hanging-​drop-based islet perifusion system for studying glucose-​stimulated insulin secretion from multiple individual pancreatic islets

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution

Targeted pharmacological therapy restores β-cell function for diabetes remission

Glucose, Adrenaline and Palmitate antagonistically regulate insulin and glucagon secretion in human pseuodislets

Modelling the endocrine pancreas in health and disease

Targeted delivery of antisense oligonucleotides to pancreatic β-cells

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Multifunctional in vivo imaging of pancreatic islets during diabetes development

Considerations for engineering composable, disease-tunable 3D human microtissues for drug discovery

Identification of proliferative and mature ß-cells in the islets of Langerhans

Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis

Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets

Tubing-free microfluidic microtissue culture system featuring gradual, in vivo-like substance exposure profiles

Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models

Microfluidic Hydrogel Hanging‐Drop Network for Long‐Term Culturing of 3D Microtissues and Simultaneous High‐Resolution Imaging

Electrical impedance spectroscopy for microtissue spheroid analysis in hanging-drop networks

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

Automated, multiplexed electrical impedance spectroscopy platform for continuous monitoring of microtissue spheroids

Adding the “heart” to hanging drop networks for microphysiological multi-tissue experiments

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

96-well format microfluidic platform for parallel interconnection of multiple multicellular spheroids

A microfluidic hanging-drop-based islet perifusion system for studying glucose-stimulated insulin secretion from multiple individual pancreatic islets